MolNFT v1 · #136543 · protein
Cytokine-receptor complex
5UWC · Interleukin-3 receptor subunit alpha: “Cytokine-receptor complex”. X-ray diffraction, 3 ligands (EDT, NAG, FUL), 4 pockets (best druggability 0.65). MolNFT v1 #136543 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5UWC
- Type
- protein
- Length
- 365 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-3 receptor subunit alpha; Interleukin-3
- UniProt
- P26951, P08700
- Ligands
- EDT, NAG, FUL
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | Interleukin-3 receptor subunit alpha | protein | 253 | 3% helix, 48% strand | P26951 |
| I | Interleukin-3 | protein | 112 | 59% helix, 0% strand | P08700 |
Ligands and binding sites
- EDT · {[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid · ligand · chains G
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains G
- FUL · beta-L-fucopyranose · sugar · chains G
- CIT · Citric acid · additive · 2 copies · chains G, I
- IMD · Imidazole · additive · chains G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 450 | 0.65 | 0.78 | 58 | empty |
| 2 | 54 | 0.42 | 0.83 | 16 | CIT |
| 3 | 85 | 0.42 | 0.79 | 17 | empty |
| 4 | 79 | 0.32 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- G–I · 1304 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5UWC · Cytokine-receptor complex · the same entry in another collection · chain G against G, TM-score 1.00
- P26951 · AlphaFold monomer V2.0 prediction for interleukin-3 receptor subunit alpha (P26951) · a predicted model of the same protein · chain G against A, TM-score 0.98
- P08700 · AlphaFold monomer V2.0 prediction for interleukin-3 (P08700) · a predicted model of the same protein · chain I against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26951
- Every structure of UniProt P08700
- Elsewhere: RCSB PDB 5UWC · PDBe 5UWC · UniProt P26951 · UniProt P08700
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