Human GRK2 in complex with gbetagamma subunits and CCG222886 (14BD)

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• SIX · 2-{5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl) oxy]methyl}piperidin-4-yl]-2-fluorophenyl}-N-[2-(1H-pyrazol-4-yl)ethyl]acetamide · ligand · chains A
• MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5UKL · Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd) · the same entry in another collection · chain A against A, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• P25098 · AlphaFold monomer V2.0 prediction for beta-adrenergic receptor kinase 1 (P25098) · a predicted model of the same protein · chain A against A, TM-score 0.98
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.88

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P25098
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Elsewhere: RCSB PDB 5UKL · PDBe 5UKL · UniProt P25098 · UniProt P62873 · UniProt P59768