MolNFT v1 · #136125 · protein
Crystal structure of a C.ELEGANS B12-trafficking protein cblc, a human mmachc homologue
5UJC · Mmachc-like protein: “Crystal structure of a C.ELEGANS B12-trafficking protein cblc, a human mmachc homologue”. X-ray diffraction, 1 ligand (COB), 1 pocket (best druggability 0.64). MolNFT v1 #136125 on GenesisL1: 3D structure…
- PDB
- 5UJC
- Type
- protein
- Length
- 267 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mmachc-like protein
- EC
- 1.16.1.-
- UniProt
- Q7Z144
- Ligands
- COB
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mmachc-like protein (EC 1.16.1.-) | protein | 267 | 43% helix, 15% strand | Q7Z144 |
Ligands and binding sites
- COB · Co-methylcobalamin · ligand · chains A
- TLA · L(+)-tartaric acid · additive · 2 copies · chains A
- TAR · D(-)-tartaric acid · additive · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 504 | 0.64 | 0.76 | 35 | COB, TLA, GOL |
Compared structures
- 5UJC · Crystal structure of a C.elegans B12-trafficking protein CblC, a human MMACHC homologue · the same entry in another collection · chain A against A, TM-score 1.00
- Q7Z144 · AlphaFold monomer V2.0 prediction for mmachc-like protein (Q7Z144) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z144
- Elsewhere: RCSB PDB 5UJC · PDBe 5UJC · UniProt Q7Z144
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