MolNFT v1 · #135939 · protein
Human alkaline sphingomyelinase (ALK-smase, ENPP7, NPP7)
5UDY · Ectonucleotide PYROPHOSPHATASE/PHOSPHODIESTERASE family…: “Human alkaline sphingomyelinase (ALK-smase, ENPP7, NPP7)”. X-ray diffraction, 5 ligands (NAG, FUC, ZN), 2 pockets (best druggability 0.54). MolNFT v1 #135939 on GenesisL1…
- PDB
- 5UDY
- Type
- protein
- Length
- 388 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ectonucleotide PYROPHOSPHATASE/PHOSPHODIESTERASE family member 7
- EC
- 3.1.4.12
- UniProt
- Q6UWV6
- Ligands
- NAG, FUC, ZN, NA, IOD
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ectonucleotide PYROPHOSPHATASE/PHOSPHODIESTERASE family member 7 (EC 3.1.4.12) | protein | 388 | 31% helix, 21% strand | Q6UWV6 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 7 copies · chains A
- FUC · alpha-L-fucopyranose · sugar · chains A
- ZN · Zinc ion · metal · 2 copies · chains A
- NA · Sodium ion · metal · chains A
- IOD · Iodide ion · ion · 25 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 238 | 0.54 | 0.77 | 31 | ZN, IOD |
| 2 | 56 | 0.42 | 0.82 | 15 | empty |
Modifications
Observed in the structure: 4 glycan (N-glycosylation).
Compared structures
- 5UDY · Human alkaline sphingomyelinase (alk-SMase, ENPP7, NPP7) · the same entry in another collection · chain A against A, TM-score 1.00
- Q6UWV6 · AlphaFold monomer V2.0 prediction for ectonucleotide PYROPHOSPHATASE/PHOSPHODIESTERASE… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6UWV6
- Elsewhere: RCSB PDB 5UDY · PDBe 5UDY · UniProt Q6UWV6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.