MolNFT v1 · #135835 · protein
Structure of apo human pycr-1 crystallized in space group P21212
5UAW · Pyrroline-5-carboxylate reductase 1, mitochondrial: “Structure of apo human pycr-1 crystallized in space group P21212”. X-ray diffraction, 1 ligand (SO4), 11 pockets (best druggability 0.76). MolNFT v1 #135835 on GenesisL1: 3D…
- PDB
- 5UAW
- Type
- protein
- Length
- 1,372 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pyrroline-5-carboxylate reductase 1, mitochondrial
- EC
- 1.5.1.2
- UniProt
- P32322
- Ligands
- SO4
- Pockets
- 11 · best druggability 0.76
Structure
x-ray diffraction · 5 distinct chains · 60% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pyrroline-5-carboxylate reductase 1, mitochondrial (EC 1.5.1.2) | protein | 263 | 61% helix, 13% strand | P32322 |
| B | Pyrroline-5-carboxylate reductase 1, mitochondrial (EC 1.5.1.2) | protein | 281 | 59% helix, 13% strand | P32322 |
| C | Pyrroline-5-carboxylate reductase 1, mitochondrial (EC 1.5.1.2) | protein | 274 | 61% helix, 14% strand | P32322 |
| D | Pyrroline-5-carboxylate reductase 1, mitochondrial (EC 1.5.1.2) | protein | 278 | 60% helix, 13% strand | P32322 |
| E | Pyrroline-5-carboxylate reductase 1, mitochondrial (EC 1.5.1.2) | protein | 276 | 61% helix, 13% strand | P32322 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 5 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1054 | 0.76 | 0.78 | 92 | SO4 |
| 2 | 708 | 0.74 | 0.80 | 76 | SO4 |
| 3 | 63 | 0.74 | 0.98 | 20 | empty |
| 4 | 517 | 0.72 | 0.81 | 65 | SO4 |
| 5 | 230 | 0.70 | 0.86 | 38 | SO4 |
Interfaces
8 interfaces between chains.
- A–B · 4435 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 4400 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 637 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 409 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 407 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5UAW · Structure of apo human PYCR-1 crystallized in space group P21212 · the same entry in another collection · chain E against E, TM-score 1.00
- P32322 · AlphaFold monomer V2.0 prediction for pyrroline-5-carboxylate reductase 1, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32322
- Elsewhere: RCSB PDB 5UAW · PDBe 5UAW · UniProt P32322
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