MolNFT v1 · #284775 · protein
AlphaFold monomer V2.0 prediction for pyrroline-5-carboxylate reductase 1, mitochondrial (P32322)
P32322: “AlphaFold monomer V2.0 prediction for pyrroline-5-carboxylate reductase 1, mitochondrial (P32322)”. 4 pockets (best druggability 0.56). MolNFT v1 #284775 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P32322
- Type
- protein
- Length
- 319 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xbb2F1C7CB3A1eeFAc24fCa72cc627162D5413FD7
- Molecule
- Pyrroline-5-carboxylate reductase 1, mitochondrial
- UniProt
- P32322
- Pockets
- 4 · best druggability 0.56
Structure
1 distinct chain · 55% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pyrroline-5-carboxylate reductase 1, mitochondrial | protein | 319 | 55% helix, 11% strand | P32322 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 402 | 0.56 | 0.73 | 40 | empty |
| 2 | 159 | 0.51 | 0.78 | 26 | empty |
| 3 | 187 | 0.46 | 0.74 | 22 | empty |
| 4 | 62 | 0.28 | 0.73 | 15 | empty |
Compared structures
- 8TD4 · Structure of PYCR1 complexed with NADH and 1,3-Dithiolane-2-carboxylic acid · an experimental structure of the same protein · chain A against A, TM-score 0.86
- 8TD3 · Structure of PYCR1 complexed with NADH and (S)-Tetrahydro-2H-pyran-2-carboxylic acid · an experimental structure of the same protein · chain A against E, TM-score 0.86
- 5UAW · Structure of apo human pycr-1 crystallized in space group P21212 · an experimental structure of the same protein · chain A against D, TM-score 0.86
- 5UAW · Structure of apo human PYCR-1 crystallized in space group P21212 · an experimental structure of the same protein · chain A against D, TM-score 0.86
- 8TD6 · Structure of PYCR1 complexed with NADH and 2-(Methylthio)acetic acid · an experimental structure of the same protein · chain A against B, TM-score 0.86
- 5UAU · Structure of human pycr-1 complexed with proline · an experimental structure of the same protein · chain A against D, TM-score 0.86
- 5UAU · Structure of human PYCR-1 complexed with proline · an experimental structure of the same protein · chain A against D, TM-score 0.86
- 6XP2 · Structure of human PYCR1 complexed with L-thiazolidine-4-carboxylate · an experimental structure of the same protein · chain A against D, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32322
- Elsewhere: UniProt P32322 · AlphaFold DB P32322
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