Structure of the irs-1 ptb domain bound to the juxtamembrane region of the insulin receptor

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 45% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 647 Ų buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).

Compared structures

• 5U1M · Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin… · the same entry in another collection · chain A against A, TM-score 1.00
• P35568 · AlphaFold monomer V2.0 prediction for insulin receptor substrate 1 (P35568) · a predicted model of the same protein · chain A against A, TM-score 0.98
• P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain B against A, TM-score 0.52

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P35568
• Every structure of UniProt P06213
• Elsewhere: RCSB PDB 5U1M · PDBe 5U1M · UniProt P35568 · UniProt P06213