MolNFT v1 · #13548 · protein

Crystal structure of human complement protein C8GAMMA at 1.2 a resolution

1LF7: “Crystal structure of human complement protein C8GAMMA at 1.2 a resolution”. X-ray diffraction, 1 pocket (best druggability 0.52). MolNFT v1 #13548 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1LF7
Type: protein
Length: 164 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Complement protein C8GAMMA
UniProt: P07360
Pockets: 1 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Complement protein C8GAMMA	protein	164	16% helix, 44% strand	P07360

Ligands and binding sites

CIT · Citric acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	230	0.52	0.76	35	CIT

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1LF7 · Crystal Structure of Human Complement Protein C8gamma at 1.2 A Resolution · the same entry in another collection · chain A against A, TM-score 1.00
P07360 · AlphaFold monomer V2.0 prediction for complement component C8 gamma chain (P07360) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07360
Elsewhere: RCSB PDB 1LF7 · PDBe 1LF7 · UniProt P07360

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