MolNFT v1 · #135272 · protein
Structure of a na+-selective mutant of two-pore channel from arabidopsis thaliana ATTPC1
5TUA · Two pore calcium channel protein 1: “Structure of a na+-selective mutant of two-pore channel from arabidopsis thaliana ATTPC1”. X-ray diffraction, 3 ligands (BA, CA, NA), 12 pockets (best druggability 0.71). MolNFT v1 #135272 on…
- PDB
- 5TUA
- Type
- protein
- Length
- 627 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Two pore calcium channel protein 1
- UniProt
- Q94KI8
- Ligands
- BA, CA, NA
- Pockets
- 12 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 76% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Two pore calcium channel protein 1 | protein | 627 | 76% helix, 1% strand | Q94KI8 |
Ligands and binding sites
- BA · Barium ion · metal · 9 copies · chains A
- CA · Calcium ion · metal · 2 copies · chains A
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 713 | 0.71 | 0.77 | 63 | empty |
| 2 | 67 | 0.69 | 0.95 | 18 | empty |
| 3 | 62 | 0.66 | 0.94 | 13 | empty |
| 4 | 217 | 0.54 | 0.77 | 33 | empty |
| 5 | 164 | 0.50 | 0.77 | 28 | empty |
Compared structures
- 5TUA · structure of a Na+-selective mutant of two-pore channel from Arabidopsis thaliana AtTPC1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q94KI8 · AlphaFold monomer V2.0 prediction for two pore calcium channel protein 1 (Q94KI8) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94KI8
- Elsewhere: RCSB PDB 5TUA · PDBe 5TUA · UniProt Q94KI8
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