Structures of the lectin IV of griffonia simplicifolia and its complex with the lewis B human blood group determinant at 2.0 ångströms resolution

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 47% strand (DSSP).

Ligands and binding sites

• FUC · alpha-L-fucopyranose · sugar · 3 copies · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
• MAG · methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside · sugar · chains A
• GAL · beta-D-galactopyranose · sugar · chains A
• MN · Manganese (II) ion · metal · chains A
• CA · Calcium ion · metal · chains A
• SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 1 glycan, 1 modified (N-glycosylation, cyclization).

Compared structures

• 1LED · Structures of the lectin IV of griffonia simplicifolia and its complex with the lewis B… · the same entry in another collection · chain A against A, TM-score 1.00
• P24146 · AlphaFold monomer V2.0 prediction for lectin-4 (P24146) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P24146
• Elsewhere: RCSB PDB 1LED · PDBe 1LED · UniProt P24146