Factor viia in complex with the inhibitor (5R)-5-[(1-aminoisoquinolin- 6-YL)AMINO]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15- DIAZATRICYCLO[14.3.1.1~6,10~]HENICOSA-1(20),6(21),7,9,16,18-hexaene- 4,14-dione

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• 7KQ · (5R)-5-[(1-aminoisoquinolin-6-yl)amino]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15-diazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9, 16,18-hexaene-4,14-dione · ligand · chains H
• CA · Calcium ion · metal · chains H
• SO4 · Sulfate ion · ion · 4 copies · chains H, L
• GOL · Glycerol · additive · 3 copies · chains H, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5TQE · Factor VIIa in complex with the inhibitor (5R)-5-[(1-aminoisoquinolin-6-yl)amino]-19-(cycl… · the same entry in another collection · chain H against H, TM-score 1.00
• P08709 · AlphaFold monomer V2.0 prediction for coagulation factor VII (P08709) · a predicted model of the same protein · chain H against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P08709
• Elsewhere: RCSB PDB 5TQE · PDBe 5TQE · UniProt P08709