MolNFT v1 · #135040 · protein

Crystal structure of the er-alpha ligand-binding domain (Y537S) in complex with the estradiol derivative, (8S,9S,13S,14S,17S)-16-(3- methoxybenzyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H- CYCLOPENTA[A]PHENANTHRENE-3,17-diol

5TMZ: “Crystal structure of the er-alpha ligand-binding domain (Y537S) in complex with the estradiol derivative…”. X-ray diffraction, 1 ligand (7FQ). MolNFT v1 #135040 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5TMZ
Type: protein
Length: 499 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P03372, Q15596
Ligands: 7FQ

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	236	—	P03372
C	—	protein	10	—	Q15596
B	—	protein	243	—	P03372
D	—	protein	10	—	Q15596

Ligands and binding sites

7FQ · (9beta,13alpha,14beta,16alpha,17alpha)-16-[(4-methoxyphenyl)methyl]estra-1,3,5(10)-triene-3,17-diol · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5TMZ · Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the… · the same entry in another collection · chain A against A, TM-score 1.00
P03372 · AlphaFold monomer V2.0 prediction for estrogen receptor (P03372) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03372
Every structure of UniProt Q15596
Elsewhere: RCSB PDB 5TMZ · PDBe 5TMZ · UniProt P03372 · UniProt Q15596

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