UniProt P03372
Estrogen Receptor (P03372)
Estrogen Receptor (UniProt P03372): 714 experimental structures and 1 predicted model on GenesisL1, 270 ligands bound, 1,403 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P03372
- Protein
- Estrogen Receptor
- Experimental structures
- 714
- Predicted models
- 1
- Ligands
- 270
- Pockets
- 1,403 · 162 records with a druggable one
Structures
715 records of P03372 in the MolNFT archive: 714 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A52 | Estrogen receptor alpha ligand-binding domain complexed to estradiol | x-ray diffraction | A, B | — | — |
| 1A52 | Estrogen receptor alpha ligand-binding domain complexed to estradiol | x-ray diffraction | A, B | — | — |
| 1ERE | Human estrogen receptor ligand-binding domain in complex with 17BETA-estradiol | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1ERE | Human estrogen receptor ligand-binding domain in complex with 17BETA-estradiol | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1ERR | Human estrogen receptor ligand-binding domain in complex with raloxifene | x-ray diffraction | A, B | — | — |
| 1ERR | Human estrogen receptor ligand-binding domain in complex with raloxifene | x-ray diffraction | A, B | — | — |
| 1G50 | Crystal structure of a wild type her alpha lbd at 2.9 ångström resolution | x-ray diffraction | A, B, C | — | — |
| 1G50 | Crystal structure of a wild type her alpha lbd at 2.9 ångström resolution | x-ray diffraction | A, B, C | — | — |
| 1GWQ | Human oestrogen receptor alpha ligand-binding domain in complex with raloxifene core and TIF2… | x-ray diffraction | A, B | — | — |
| 1GWQ | Human oestrogen receptor alpha ligand-binding domain in complex with raloxifene core and TIF2… | x-ray diffraction | A, B | — | — |
| 1GWR | Human oestrogen receptor alpha ligand-binding domain in complex with 17BETA-oestradiol and TIF2… | x-ray diffraction | A, B | — | — |
| 1GWR | Human oestrogen receptor alpha ligand-binding domain in complex with 17BETA-oestradiol and TIF2… | x-ray diffraction | A, B | — | — |
| 1HCP | DNA recognition by the oestrogen receptor: from solution to the crystal | solution nmr | A | — | — |
| 1HCP | DNA recognition by the oestrogen receptor: from solution to the crystal | solution nmr | A | — | — |
| 1HCQ | The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors… | x-ray diffraction | A, B, E, F | — | — |
| 1HCQ | The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors… | x-ray diffraction | A, B, E, F | — | — |
| 1L2I | Human Estrogen Receptor alpha Ligand-binding Domain in Complex with… | x-ray diffraction | A, B | — | — |
| 1L2I | Human estrogen receptor alpha ligand-binding domain in complex with… | x-ray diffraction | A, B | — | — |
| 1PCG | Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator… | x-ray diffraction | A, B | — | — |
| 1PCG | Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator… | x-ray diffraction | A, B | — | — |
| 1QKT | Mutant estrogen nuclear receptor ligand binding domain complexed with estradiol | x-ray diffraction | A | — | — |
| 1QKT | Mutant estrogen nuclear receptor ligand binding domain complexed with estradiol | x-ray diffraction | A | — | — |
| 1QKU | Wild type estrogen nuclear receptor ligand binding domain complexed with estradiol | x-ray diffraction | A, B, C | — | — |
| 1QKU | Wild type estrogen nuclear receptor ligand binding domain complexed with estradiol | x-ray diffraction | A, B, C | — | — |
| 1R5K | Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638 | x-ray diffraction | A, B, C | — | — |
| 1R5K | Human estrogen receptor alpha ligand-binding domain in complex with GW5638 | x-ray diffraction | A, B, C | — | — |
| 1SJ0 | Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D | x-ray diffraction | A | — | — |
| 1SJ0 | Human estrogen receptor alpha ligand-binding domain in complex with the antagonist ligand 4-D | x-ray diffraction | A | — | — |
| 1UOM | The Structure of Estrogen Receptor in Complex with a Selective and Potent Tetrahydroisochiolin… | x-ray diffraction | A | — | — |
| 1UOM | The structure of estrogen receptor in complex with a selective and potent tetrahydroisochiolin… | x-ray diffraction | A | — | — |
| 1X7E | Crystal structure of estrogen receptor alpha complexed with way-244 | x-ray diffraction | A, B | — | — |
| 1X7E | Crystal structure of estrogen receptor alpha complexed with way-244 | x-ray diffraction | A, B | — | — |
| 1X7R | Crystal structure of estrogen receptor alpha complexed with genistein | x-ray diffraction | A | — | — |
| 1X7R | Crystal structure of estrogen receptor alpha complexed with genistein | x-ray diffraction | A | — | — |
| 1XP1 | Human estrogen receptor alpha ligand-binding domain in complex with compound 15 | x-ray diffraction | A | — | — |
| 1XP1 | Human estrogen receptor alpha ligand-binding domain in complex with compound 15 | x-ray diffraction | A | — | — |
| 1XP6 | Human estrogen receptor alpha ligand-binding domain in complex with compound 16 | x-ray diffraction | A | — | — |
| 1XP6 | Human estrogen receptor alpha ligand-binding domain in complex with compound 16 | x-ray diffraction | A | — | — |
| 1XP9 | Human estrogen receptor alpha ligand-binding domain in complex with compound 18 | x-ray diffraction | A | — | — |
| 1XP9 | Human estrogen receptor alpha ligand-binding domain in complex with compound 18 | x-ray diffraction | A | — | — |
| 1XPC | Human estrogen receptor alpha ligand-binding domain in complex with compound 19 | x-ray diffraction | A | — | — |
| 1XPC | Human estrogen receptor alpha ligand-binding domain in complex with compound 19 | x-ray diffraction | A | — | — |
| 1XQC | X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution | x-ray diffraction | A, B, C, D | — | — |
| 1XQC | X-ray structure of eralpha lbd bound to a tetrahydroisoquinoline serm ligand at 2.05A resolution | x-ray diffraction | A, B, C, D | — | — |
| 1YIM | Human estrogen receptor alpha ligand-binding domain in complex with compound 4 | x-ray diffraction | A | — | — |
| 1YIM | Human estrogen receptor alpha ligand-binding domain in complex with compound 4 | x-ray diffraction | A | — | — |
| 1YIN | Human estrogen receptor alpha ligand-binding domain in complex with compound 3F | x-ray diffraction | A | — | — |
| 1YIN | Human estrogen receptor alpha ligand-binding domain in complex with compound 3F | x-ray diffraction | A | — | — |
| 1ZKY | Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-3M and A Glucocorticoid… | x-ray diffraction | A, B | — | — |
| 1ZKY | Human estrogen receptor alpha ligand-binding domain in complex with obcp-3M and a glucocorticoid… | x-ray diffraction | A, B | — | — |
| 2AYR | A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus… | x-ray diffraction | A | — | — |
| 2AYR | A serm designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus… | x-ray diffraction | A | — | — |
| 2B1V | Human estrogen receptor alpha ligand-binding domain in complex with OBCP-1M and a glucocorticoid… | x-ray diffraction | A, B | — | — |
| 2B1V | Human estrogen receptor alpha ligand-binding domain in complex with obcp-1M and a glucocorticoid… | x-ray diffraction | A, B | — | — |
| 2B1Z | Human estrogen receptor alpha ligand-binding domain in complex with… | x-ray diffraction | A, B | — | — |
| 2B1Z | Human estrogen receptor alpha ligand-binding domain in complex with… | x-ray diffraction | A, B | — | — |
| 2B23 | Human estrogen receptor alpha ligand-binding domain and a glucocorticoid receptor-interacting… | x-ray diffraction | A, B | — | — |
| 2B23 | Human estrogen receptor alpha ligand-binding domain and a glucocorticoid receptor-interacting… | x-ray diffraction | A, B | — | — |
| 2BJ4 | Estrogen receptor alpha lbd in complex with a phage-display derived peptide antagonist | x-ray diffraction | A, B | — | — |
| 2BJ4 | Estrogen receptor alpha lbd in complex with a phage-display derived peptide antagonist | x-ray diffraction | A, B | — | — |
655 records more on the page itself.
Ligands
- EST · Estradiol · in 15 records
- CL · Chloride ion · in 14 records
- G9J · (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol · in 8 records
- OHT · 4-hydroxytamoxifen · in 6 records
- C6V · Lsz102 · in 4 records
- F3D · 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide · in 4 records
- R3V · (5R,6S)-5-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol · in 4 records
- RAL · Raloxifene · in 4 records
- RL4 · (5R,6S)-5-(4-{2-[(2R)-2-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol · in 4 records
- 6WV · (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-phenylazanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol · in 3 records
- 7EE · (14beta,17alpha)-21-(4-aminophenyl)-19-norpregna-1(10), 2,4-trien-20-yne-3,17-diol · in 3 records
- 7EH · 3-methyl-6-phenyl-3H-imidazo[4,5-b]pyridin-2-amine · in 3 records
- C3D · (5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol · in 3 records
- NI · Nickel (II) ion · in 3 records
- OBT · (1S,2R,4S)-N-(4-chlorophenyl)-5,6-bis(4-hydroxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide · in 3 records
- 0AW · ~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-5-carboxamide · in 2 records
- 0B7 · ~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-1~{H}-indole-6-carboxamide · in 2 records
- 29S · Bazedoxifene · in 2 records
- 53Q · Clomifene · in 2 records
- 5VP · 4-{[(2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl) amino]methyl}phenol · in 2 records
- 5YR · 10-{[3,17beta-dihydroxyestra-1,3,5(10)-trien-7beta-yl]sulfanyl}-N-methyl-N-propyldecanamide · in 2 records
- 61Z · 2-(2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-isoindol-5-ol · in 2 records
- 6WL · 4-[1-methyl-7-(trifluoromethyl)indazol-3-yl]benzene-1, 3-diol · in 2 records
- 6WM · (8~{R},9~{S},13~{S},14~{S},16~{R},17~{S})-13-methyl-16-(phenylmethyl)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol · in 2 records
- 6WN · (8~{R},9~{S},13~{S},14~{S},16~{E})-13-methyl-3-oxidanyl-16-(phenylmethylidene)-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-one · in 2 records
- 6WP · naphthalen-1-yl (1~{S},2~{R},4~{S})-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate · in 2 records
- 6WQ · 4-[(5-bromanyl-2,3-dihydroinden-1-ylidene)-(4-hydroxyphenyl)methyl]phenol · in 2 records
- 6WR · (1~{S},3~{a}~{R},7~{a}~{S})-5-(2-chloranyl-4-oxidanyl-phenyl)-2,3,3~{a},4,7,7~{a}-hexahydro-1~{H}-inden-1-ol · in 2 records
- 6WS · 1-[2,2-bis(chloranyl)-1-(4-chlorophenyl)ethenyl]-4-chloranyl-benzene · in 2 records
- 6WT · 1-chloranyl-4-[2,2,2-tris(chloranyl)-1-(4-chlorophenyl)ethyl]benzene · in 2 records
Experiment against prediction
- 5WGD chain B against the predicted model P03372: TM-score 0.99, RMSD 0.47 Å
- 5WGD chain B against the predicted model P03372: TM-score 0.99, RMSD 0.47 Å
- 5WGQ chain B against the predicted model P03372: TM-score 0.99, RMSD 0.48 Å
- 5WGQ chain B against the predicted model P03372: TM-score 0.99, RMSD 0.48 Å
- 5KR9 chain B against the predicted model P03372: TM-score 0.99, RMSD 0.48 Å
- 5KR9 chain B against the predicted model P03372: TM-score 0.99, RMSD 0.48 Å
- 5TLP chain B against the predicted model P03372: TM-score 0.99, RMSD 0.45 Å
- 5TN5 chain B against the predicted model P03372: TM-score 0.99, RMSD 0.49 Å
- 5TN5 chain B against the predicted model P03372: TM-score 0.99, RMSD 0.49 Å
- 5T92 chain A against the predicted model P03372: TM-score 0.99, RMSD 0.44 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.