MolNFT v1 · #135013 · protein

Crystal structure of the er-alpha ligand-binding domain (Y537S) in complex with the obhs-asc compound, 5-(4-((1R,4S,6R)-6-((4- BROMOPHENOXY)SULFONYL)-3-(4-hydroxyphenyl)-7-OXABICYCLO[2.2.1]HEPT-2- en-2-YL)PHENOXY)PENTANOIC acid

5TM5: “Crystal structure of the er-alpha ligand-binding domain (Y537S) in complex with the obhs-asc compound…”. X-ray diffraction, 1 ligand (7EV). MolNFT v1 #135013 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5TM5
Type: protein
Length: 491 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P03372, Q15596
Ligands: 7EV

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	239	—	P03372
B	—	protein	233	—	P03372
C	—	protein	9	—	Q15596
D	—	protein	10	—	Q15596

Ligands and binding sites

7EV · 5-{4-[(1S,4S,5R)-5-[(4-bromophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenoxy}pentanoic acid · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5TM5 · Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the… · the same entry in another collection · chain C against C, TM-score 1.00
P03372 · AlphaFold monomer V2.0 prediction for estrogen receptor (P03372) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03372
Every structure of UniProt Q15596
Elsewhere: RCSB PDB 5TM5 · PDBe 5TM5 · UniProt P03372 · UniProt Q15596

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.