MolNFT v1 · #135010 · protein
Crystal structure of the er-alpha ligand-binding domain (Y537S) in complex with 2,5-BIS(2-chloro-4-HYDROXYPHENYL)THIOPHENE 1-oxide
5TM2: “Crystal structure of the er-alpha ligand-binding domain (Y537S) in complex with…”. X-ray diffraction, 1 ligand (7EO). MolNFT v1 #135010 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TM2
- Type
- protein
- Length
- 466 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P03372, Q15596
- Ligands
- 7EO
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 217 | — | P03372 |
| B | — | protein | 231 | — | P03372 |
| C, D | — | protein | 9 | — | Q15596 |
Ligands and binding sites
- 7EO · 2,5-bis(2-chloro-4-hydroxyphenyl)-1H-1lambda~4~-thiophen-1-one · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5TM2 · Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P03372 · AlphaFold monomer V2.0 prediction for estrogen receptor (P03372) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03372
- Every structure of UniProt Q15596
- Elsewhere: RCSB PDB 5TM2 · PDBe 5TM2 · UniProt P03372 · UniProt Q15596
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