Crystal structure of the human cannabinoid receptor CB1

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• OLA · Oleic acid · ligand · 3 copies · chains A
• ZDG · 4-[4-[2-(2,4-dichlorophenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)pyrazol-3-yl]phenyl]but-3-ynyl nitrate · ligand · chains A
• FMN · Flavin mononucleotide · ligand · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · chains A
• PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5TGZ · Crystal Structure of the Human Cannabinoid Receptor CB1 · the same entry in another collection · chain A against A, TM-score 1.00
• P21554 · AlphaFold monomer V2.0 prediction for cannabinoid receptor 1 (P21554) · a predicted model of the same protein · chain A against A, TM-score 0.62
• P00323 · AlphaFold monomer V2.0 prediction for flavodoxin (P00323) · a predicted model of the same protein · chain A against A, TM-score 0.33

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P21554
• Every structure of UniProt P00323
• Elsewhere: RCSB PDB 5TGZ · PDBe 5TGZ · UniProt P21554 · UniProt P00323