MolNFT v1 · #134798 · protein
Crystal structure of the SETDB2 amino terminal domain
5TFP · Histone-lysine N-methyltransferase SETDB2: “Crystal structure of the SETDB2 amino terminal domain”. X-ray diffraction. MolNFT v1 #134798 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TFP
- Type
- protein
- Length
- 118 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-lysine N-methyltransferase SETDB2
- EC
- 2.1.1.43
- UniProt
- Q96T68
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.43) | protein | 59 | 78% helix, 0% strand | Q96T68 |
| B | Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.43) | protein | 59 | 76% helix, 0% strand | Q96T68 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 1760 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 5TFP · Crystal Structure of the SETDB2 Amino Terminal Domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q96T68 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETDB2 (Q96T68) · a predicted model of the same protein · chain B against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96T68
- Elsewhere: RCSB PDB 5TFP · PDBe 5TFP · UniProt Q96T68
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