UniProt Q96T68
Histone-lysine N-methyltransferase SETDB2 (Q96T68)
Histone-lysine N-methyltransferase SETDB2 (UniProt Q96T68), EC 2.1.1.366: 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96T68
- Protein
- Histone-lysine N-methyltransferase SETDB2
- EC
- 2.1.1.366
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 7 · 2 records with a druggable one
Structures
3 records of Q96T68 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5TFP | Crystal structure of the SETDB2 amino terminal domain | x-ray diffraction | A, B | — | — |
| 8HFP | Crystal structure of the methyl-CpG-binding domain of SETDB2 in complex with the cysteine-rich… | x-ray diffraction | C, D | ZN, SO4 | 2 (best 0.53) |
| Q96T68 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETDB2 (Q96T68) | predicted | A | — | 5 (best 0.75) |
Ligands
Experiment against prediction
- 8HFP chain D against the predicted model Q96T68: TM-score 0.90, RMSD 1.39 Å
- 8HFP chain C against the predicted model Q96T68: TM-score 0.89, RMSD 1.78 Å
- 5TFP chain B against the predicted model Q96T68: TM-score 0.80, RMSD 1.81 Å
- 5TFP chain A against the predicted model Q96T68: TM-score 0.77, RMSD 1.76 Å
Elsewhere
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