MolNFT v1 · #13478 · protein
Streptavidin-homobiotin complex
1LCW: “Streptavidin-homobiotin complex”. X-ray diffraction, 1 ligand (SHM), 3 pockets (best druggability 0.47). MolNFT v1 #13478 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1LCW
- Type
- protein
- Length
- 238 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Streptavidin
- UniProt
- P22629
- Ligands
- SHM
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Streptavidin | protein | 119 | 5% helix, 57% strand | P22629 |
Ligands and binding sites
- SHM · Homobiotin · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.47 | 0.80 | 17 | SHM |
| 2 | 102 | 0.45 | 0.79 | 17 | SHM |
| 3 | 50 | 0.28 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1625 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 1LCW · streptavidin-homobiotin complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22629
- Elsewhere: RCSB PDB 1LCW · PDBe 1LCW · UniProt P22629
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