MolNFT v1 · #134663 · protein
Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bound with inhibitor DSM421
5TBO: “Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bound with inhibitor DSM421”. X-ray diffraction, 3 ligands (78Z, FMN, ORO). MolNFT v1 #134663 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TBO
- Type
- protein
- Length
- 362 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q08210
- Ligands
- 78Z, FMN, ORO
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 362 | — | Q08210 |
Ligands and binding sites
- 78Z · 2-(1,1-difluoroethyl)-5-methyl-N-[6-(trifluoromethyl) pyridin-3-yl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine · ligand · chains A
- FMN · Flavin mononucleotide · ligand · chains A
- ORO · Orotic acid · ligand · chains A
- GOL · Glycerol · additive · 2 copies · chains A
- LDA · Lauryl dimethylamine-N-oxide · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- Q08210 · AlphaFold monomer V2.0 prediction for dihydroorotate dehydrogenase (quinone)… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08210
- Elsewhere: RCSB PDB 5TBO · PDBe 5TBO · UniProt Q08210
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