MolNFT v1 · #134441 · protein
Crystal structure of the D. melanogaster EIF4E-EIF4G complex without lateral contact
5T48 · Eukaryotic translation initiation factor 4E: “Crystal structure of the D. melanogaster EIF4E-EIF4G complex without lateral contact”. X-ray diffraction, 1 ligand (MGP), 2 pockets (best druggability 0.50). MolNFT v1 #134441 on…
- PDB
- 5T48
- Type
- protein
- Length
- 217 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E; Eukaryotic translation initiation factor 4G…
- UniProt
- P48598, O61380
- Ligands
- MGP
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E | protein | 181 | 31% helix, 28% strand | P48598 |
| B | Eukaryotic translation initiation factor 4G, isoform a | protein | 36 | 25% helix, 11% strand | O61380 |
Ligands and binding sites
- MGP · 7-methyl-guanosine-5'-triphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 112 | 0.50 | 0.81 | 18 | empty |
| 2 | 154 | 0.48 | 0.77 | 26 | MGP |
Interfaces
1 interface between chains.
- A–B · 782 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- P48598 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E1… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48598
- Every structure of UniProt O61380
- Elsewhere: RCSB PDB 5T48 · PDBe 5T48 · UniProt P48598 · UniProt O61380
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