UniProt P48598
Eukaryotic translation initiation factor 4E (P48598)
Eukaryotic translation initiation factor 4E (UniProt P48598): 19 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P48598
- Protein
- Eukaryotic translation initiation factor 4E
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 20 · 1 record with a druggable one
Structures
20 records of P48598 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4AXG | Structure of eIF4E-Cup complex | x-ray diffraction | A, B | — | — |
| 4AXG | Structure of EIF4E-cup complex | x-ray diffraction | A, B | — | — |
| 4UE8 | Complex of D. melanogaster eIF4E with the 4E binding protein Thor | x-ray diffraction | A | — | — |
| 4UE8 | Complex of D. melanogaster EIF4E with the 4E binding protein thor | x-ray diffraction | A | — | — |
| 4UE9 | Complex of D. melanogaster eIF4E with the 4E-binding protein 4E-T | x-ray diffraction | A | — | — |
| 4UE9 | Complex of D. melanogaster EIF4E with the 4E-binding protein 4E-T | x-ray diffraction | A | — | — |
| 4UEA | Complex of D. melanogaster eIF4E with a designed 4E-binding protein (Form I) | x-ray diffraction | A, C, E | — | — |
| 4UEA | Complex of D. melanogaster EIF4E with a designed 4E-binding protein (form I) | x-ray diffraction | A, C, E | — | — |
| 4UEB | Complex of D. melanogaster eIF4E with a designed 4E-binding protein (Form II) | x-ray diffraction | A, C, E | — | — |
| 4UEB | Complex of D. melanogaster EIF4E with a designed 4E-binding protein (form II) | x-ray diffraction | A, C, E | — | — |
| 4UEC | Complex of D. melanogaster eIF4E with eIF4G and cap analog | x-ray diffraction | A, C | — | — |
| 4UEC | Complex of D. melanogaster EIF4E with EIF4G and cap analog | x-ray diffraction | A, C | — | — |
| 5ABU | Complex of D. melanogaster eIF4E with the 4E-binding protein Mextli and cap analog | x-ray diffraction | A | — | — |
| 5ABU | Complex of D. melanogaster EIF4E with the 4E-binding protein mextli and cap analog | x-ray diffraction | A | — | — |
| 5ABV | Complex of D. melanogaster eIF4E with the 4E-binding protein Mextli | x-ray diffraction | A, C, E, G | — | 13 (best 0.49) |
| 5ABV | Complex of D. melanogaster EIF4E with the 4E-binding protein mextli | x-ray diffraction | A, C, E, G | — | — |
| 5T47 | Crystal structure of the D. melanogaster eIF4E-eIF4G complex | x-ray diffraction | A, C | — | 7 (best 0.74) |
| 5T47 | Crystal structure of the D. melanogaster EIF4E-EIF4G complex | x-ray diffraction | A, C | — | — |
| 5T48 | Crystal structure of the D. melanogaster EIF4E-EIF4G complex without lateral contact | x-ray diffraction | A | MGP | — |
| P48598 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E1 (P48598) | predicted | A | — | — |
Ligands
- MGP · 7-methyl-guanosine-5'-triphosphate · in 1 record
Experiment against prediction
- 5ABU chain A against the predicted model P48598: TM-score 0.99, RMSD 0.52 Å
- 5ABU chain A against the predicted model P48598: TM-score 0.99, RMSD 0.52 Å
- 5T48 chain A against the predicted model P48598: TM-score 0.99, RMSD 0.56 Å
- 4AXG chain B against the predicted model P48598: TM-score 0.99, RMSD 0.58 Å
- 4AXG chain B against the predicted model P48598: TM-score 0.99, RMSD 0.58 Å
- 4UEA chain E against the predicted model P48598: TM-score 0.98, RMSD 0.78 Å
- 4UEA chain E against the predicted model P48598: TM-score 0.98, RMSD 0.78 Å
- 4UEB chain A against the predicted model P48598: TM-score 0.98, RMSD 0.74 Å
- 4UEB chain A against the predicted model P48598: TM-score 0.98, RMSD 0.74 Å
- 5T47 chain A against the predicted model P48598: TM-score 0.98, RMSD 0.68 Å
Elsewhere
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