MolNFT v1 · #133845 · protein
Structure of liver pyruvate kinase in complex with anthraquinone derivative 105
5SCI: “Structure of liver pyruvate kinase in complex with anthraquinone derivative 105”. X-ray diffraction, 5 ligands (FBP, OXL, I9F). MolNFT v1 #133845 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5SCI
- Type
- protein
- Length
- 3,405 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q16716
- Ligands
- FBP, OXL, I9F, MG, K
Structure
x-ray diffraction · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 422 | — | Q16716 |
| B | — | protein | 435 | — | Q16716 |
| C | — | protein | 425 | — | Q16716 |
| D, H | — | protein | 425 | — | Q16716 |
| E | — | protein | 419 | — | Q16716 |
| F | — | protein | 433 | — | Q16716 |
| G | — | protein | 421 | — | Q16716 |
Ligands and binding sites
- FBP · 1,6-di-O-phosphono-beta-D-fructofuranose · ligand · 8 copies · chains A, B, C, G, D, E, F, H
- OXL · Oxalate ion · ligand · 8 copies · chains A, B, C, D, E, F, G, H
- I9F · dimethyl (2R)-2-hydroxy-2-{2-[4-(3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)piperazin-1-yl]-2-oxoethyl}butanedioate · ligand · 4 copies · chains C, E, F, G
- MG · Magnesium ion · metal · 8 copies · chains A, B, C, D, E, F, G, H
- K · Potassium ion · metal · 8 copies · chains A, B, C, D, E, F, G, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5SCI · Structure of liver pyruvate kinase in complex with anthraqui derivative 105 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16716
- Elsewhere: RCSB PDB 5SCI · PDBe 5SCI · UniProt Q16716
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