UniProt Q16716
Pyruvate kinase (Q16716)
Pyruvate kinase (UniProt Q16716), EC 2.7.1.40: 23 experimental structures on GenesisL1, 19 ligands bound, 120 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q16716
- Protein
- Pyruvate kinase
- EC
- 2.7.1.40
- Experimental structures
- 23
- Predicted models
- 0
- Ligands
- 19
- Pockets
- 120 · 6 records with a druggable one
Structures
23 records of Q16716 in the MolNFT archive: 23 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5SC8 | Structure of liver pyruvate kinase in complex with anthraquinone derivative 17 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, E6K, MG, K | — |
| 5SC9 | Structure of liver pyruvate kinase in complex with anthraquinone derivative 29 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, I7K, MG | — |
| 5SCA | Structure of liver pyruvate kinase in complex with anthraquinone derivative 36 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, I7N, MG, K | — |
| 5SCB | Structure of liver pyruvate kinase in complex with anthraqui derivative 28 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, I7V, MG, K | 20 (best 0.87) |
| 5SCB | Structure of liver pyruvate kinase in complex with anthraquinone derivative 28 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, I7V, MG, K | — |
| 5SCC | Structure of liver pyruvate kinase in complex with anthraqui derivative 57 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I8Q | 20 (best 0.87) |
| 5SCC | Structure of liver pyruvate kinase in complex with anthraquinone derivative 57 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I8Q | — |
| 5SCD | Structure of liver pyruvate kinase in complex with anthraqui derivative 58 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I8U | 20 (best 0.87) |
| 5SCD | Structure of liver pyruvate kinase in complex with anthraquinone derivative 58 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I8U | — |
| 5SCE | Structure of liver pyruvate kinase in complex with anthraquinone derivative 55 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I8Y | — |
| 5SCF | Structure of liver pyruvate kinase in complex with anthraqui derivative 99 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I91 | — |
| 5SCF | Structure of liver pyruvate kinase in complex with anthraquinone derivative 99 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I91 | — |
| 5SCG | Structure of liver pyruvate kinase in complex with anthraqui derivative 101 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, I99, MG, K | 20 (best 0.87) |
| 5SCG | Structure of liver pyruvate kinase in complex with anthraquinone derivative 101 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, I99, MG, K | — |
| 5SCH | Structure of liver pyruvate kinase in complex with anthraqui derivative 100 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I9C | — |
| 5SCH | Structure of liver pyruvate kinase in complex with anthraquinone derivative 100 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I9C | — |
| 5SCI | Structure of liver pyruvate kinase in complex with anthraqui derivative 105 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I9F | 20 (best 0.87) |
| 5SCI | Structure of liver pyruvate kinase in complex with anthraquinone derivative 105 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I9F | — |
| 5SCJ | Structure of liver pyruvate kinase in complex with anthraqui derivative 106 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I9K | 20 (best 0.87) |
| 5SCJ | Structure of liver pyruvate kinase in complex with anthraquinone derivative 106 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I9K | — |
| 5SCK | Structure of liver pyruvate kinase in complex with anthraquinone derivative 42 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, I9N | — |
| 5SCL | Structure of liver pyruvate kinase in complex with anthraquinone derivative 1 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, AZN, MG, K | — |
| 5SDT | Structure of liver pyruvate kinase in complex with anthraquinone derivative 15 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, I9Q, MG, K | — |
Ligands
- FBP · 1,6-di-O-phosphono-beta-D-fructofuranose · in 23 records
- MG · Magnesium ion · in 23 records
- OXL · Oxalate ion · in 23 records
- K · Potassium ion · in 22 records
- I7V · (3R)-1-(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)piperidine-3-carboxylic acid · in 2 records
- I8Q · 4-amino-3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid · in 2 records
- I8U · 3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid · in 2 records
- I91 · N-(3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)glycine · in 2 records
- I99 · (3R)-1-(3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)piperidine-3-carboxylic acid · in 2 records
- I9C · methyl N-(3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)glycinate · in 2 records
- I9F · dimethyl (2R)-2-hydroxy-2-{2-[4-(3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)piperazin-1-yl]-2-oxoethyl}butanedioate · in 2 records
- I9K · (2R)-2-hydroxy-2-{2-[4-(3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)piperazin-1-yl]-2-oxoethyl}butanedioic acid · in 2 records
- AZN · Alizarin red · in 1 record
- E6K · 5-[(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)amino]pentanoic acid · in 1 record
- I7K · 1-(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)piperidine-4-carboxylic acid · in 1 record
- I7N · N-[(3R)-1-(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)piperidine-3-carbonyl]-L-aspartic acid · in 1 record
- I8Y · 3-amino-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid · in 1 record
- I9N · 1,2-dihydroxy-3-(piperazine-1-sulfonyl)anthracene-9,10-dione · in 1 record
- I9Q · N-(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)-beta-alanine · in 1 record
Elsewhere
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