Pandda analysis group deposition of models with modelled events (E.G. bound ligands) -- crystal structure of human FAM83B in complex with FMOPL000271A

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 33% strand (DSSP).

Ligands and binding sites

• GOJ · ethyl 1~{H}-pyrazole-4-carboxylate · ligand · 2 copies · chains A, B
• IOD · Iodide ion · ion · 4 copies · chains A
• EDO · 1,2-ethanediol · additive · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1453 Ų buried · 25 hydrogen bonds · protein-protein

Compared structures

• 5QHI · PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)… · the same entry in another collection · chain A against A, TM-score 1.00
• Q5T0W9 · AlphaFold monomer V2.0 prediction for protein FAM83B (Q5T0W9) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q5T0W9
• Elsewhere: RCSB PDB 5QHI · PDBe 5QHI · UniProt Q5T0W9