MolNFT v1 · #129853 · protein

Human STK10 bound to dasatinib

5OWR · SERINE/THREONINE-protein kinase 10: “Human STK10 bound to dasatinib”. X-ray diffraction, 2 ligands (1N1, CA), 2 pockets (best druggability 0.57). MolNFT v1 #129853 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5OWR
Type: protein
Length: 282 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase 10
EC: 2.7.11.1
UniProt: O94804
Ligands: 1N1, CA
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase 10 (EC 2.7.11.1)	protein	282	44% helix, 16% strand	O94804

Ligands and binding sites

1N1 · N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide · ligand · chains A
CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	261	0.57	0.77	27	1N1
2	286	0.54	0.75	38	empty

Compared structures

O94804 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 10 (O94804) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O94804
Elsewhere: RCSB PDB 5OWR · PDBe 5OWR · UniProt O94804

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