MolNFT v1 · #129760 · protein
Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8CYS/THR11CYS
5OTX · Glucagon-like peptide 1 receptor: “Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8CYS/THR11CYS”. X-ray diffraction, 4 pockets (best druggability 0.48). MolNFT v1 #129760 on GenesisL1: 3D structure, binding…
- PDB
- 5OTX
- Type
- protein
- Length
- 256 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucagon-like peptide 1 receptor; Glucagon
- UniProt
- P43220, P01275
- Pockets
- 4 · best druggability 0.48
Structure
x-ray diffraction · 3 distinct chains · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glucagon-like peptide 1 receptor | protein | 101 | 27% helix, 22% strand | P43220 |
| B | Glucagon | protein | 26 | 81% helix, 0% strand | P01275 |
| D | Glucagon | protein | 28 | 75% helix, 0% strand | P01275 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 179 | 0.48 | 0.76 | 22 | empty |
| 2 | 116 | 0.41 | 0.76 | 25 | empty |
| 3 | 73 | 0.35 | 0.76 | 18 | empty |
| 4 | 90 | 0.34 | 0.74 | 22 | empty |
Interfaces
3 interfaces between chains.
- C–D · 543 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 519 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 255 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 5OTX · Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cys/Thr11Cys · the same entry in another collection · chain A against A, TM-score 1.00
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P01275 · AlphaFold monomer V2.0 prediction for pro-glucagon (P01275) · a predicted model of the same protein · chain B against A, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43220
- Every structure of UniProt P01275
- Elsewhere: RCSB PDB 5OTX · PDBe 5OTX · UniProt P43220 · UniProt P01275
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