MolNFT v1 · #129163 · protein

Crystal structure of human TMEM16K / anoctamin 10

5OC9 · Anoctamin-10: “Crystal structure of human TMEM16K / anoctamin 10”. X-ray diffraction, 2 ligands (79M, CA), 20 pockets (best druggability 0.81). MolNFT v1 #129163 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5OC9
Type: protein
Length: 1,223 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anoctamin-10
UniProt: Q9NW15
Ligands: 79M, CA
Pockets: 20 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 66% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Anoctamin-10	protein	607	66% helix, 8% strand	Q9NW15
B	Anoctamin-10	protein	616	66% helix, 8% strand	Q9NW15

Ligands and binding sites

79M · (2R)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate · ligand · 18 copies · chains A, B
CA · Calcium ion · metal · 7 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	600	0.81	0.87	67	empty
2	982	0.77	0.79	73	empty
3	776	0.77	0.81	73	empty
4	579	0.73	0.80	59	79M
5	625	0.71	0.79	43	empty

Interfaces

1 interface between chains.

A–B · 1822 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

5OC9 · Crystal Structure of human TMEM16K / Anoctamin 10 · the same entry in another collection · chain A against A, TM-score 1.00
Q9NW15 · AlphaFold monomer V2.0 prediction for anoctamin-10 (Q9NW15) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NW15
Elsewhere: RCSB PDB 5OC9 · PDBe 5OC9 · UniProt Q9NW15

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