MolNFT v1 · #128830 · protein
Crystal structure of WNK3 kinase and CCT1 didomain in a unphosphorylated state
5O2C · SERINE/THREONINE-protein kinase WNK3: “Crystal structure of WNK3 kinase and CCT1 didomain in a unphosphorylated state”. X-ray diffraction, 4 pockets (best druggability 0.71). MolNFT v1 #128830 on GenesisL1: 3D structure, binding…
- PDB
- 5O2C
- Type
- protein
- Length
- 368 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase WNK3
- EC
- 2.7.11.1
- UniProt
- Q9BYP7
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase WNK3 (EC 2.7.11.1) | protein | 368 | 41% helix, 20% strand | Q9BYP7 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 341 | 0.71 | 0.83 | 36 | GOL |
| 2 | 294 | 0.68 | 0.83 | 32 | empty |
| 3 | 72 | 0.41 | 0.80 | 13 | empty |
| 4 | 98 | 0.39 | 0.76 | 19 | empty |
Compared structures
- 5O2C · Crystal structure of WNK3 kinase and CCT1 didomain in a unphosphorylated state · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BYP7 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK3 (Q9BYP7) · a predicted model of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BYP7
- Elsewhere: RCSB PDB 5O2C · PDBe 5O2C · UniProt Q9BYP7
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