UniProt Q9BYP7
Serine/threonine-protein kinase WNK3 (Q9BYP7)
Serine/threonine-protein kinase WNK3 (UniProt Q9BYP7), EC 2.7.11.1: 14 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 42 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9BYP7
- Protein
- Serine/threonine-protein kinase WNK3
- EC
- 2.7.11.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 42 · 7 records with a druggable one
Structures
15 records of Q9BYP7 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5NKP | Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide | x-ray diffraction | D, C | CL | 2 (best 0.38) |
| 5NKP | Crystal structure of the human KLHL3 kelch domain in complex with a WNK3 peptide | x-ray diffraction | D, C | CL | — |
| 5O1V | Crystal structure of WNK3 kinase domain in a monophosphorylated apo state (A-loop swapped) | x-ray diffraction | A, B | — | 6 (best 0.75) |
| 5O1V | Crystal structure of WNK3 kinase domain in a monophosphorylated apo state (a-loop swapped) | x-ray diffraction | A, B | — | — |
| 5O21 | Crystal structure of WNK3 kinase domain in a monophosphorylated state with chloride bound in the… | x-ray diffraction | A, B | CL | — |
| 5O23 | Crystal structure of WNK3 kinase domain in a monophosphorylated apo state | x-ray diffraction | A, B | SO4 | 8 (best 0.83) |
| 5O23 | Crystal structure of WNK3 kinase domain in a monophosphorylated apo state | x-ray diffraction | A, B | SO4 | — |
| 5O26 | Crystal structure of WNK3 kinase domain in a diphosphorylated state and in complex with AMP-PNP/Mg2+ | x-ray diffraction | A, B | ANP, MG | 5 (best 0.72) |
| 5O26 | Crystal structure of WNK3 kinase domain in a diphosphorylated state and in complex with AMP-PNP/MG2+ | x-ray diffraction | A, B | ANP, MG | — |
| 5O2B | Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the… | x-ray diffraction | A, B | KS1, NA | 4 (best 0.72) |
| 5O2B | Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the… | x-ray diffraction | A, B | KS1, NA | — |
| 5O2C | Crystal structure of WNK3 kinase and CCT1 didomain in a unphosphorylated state | x-ray diffraction | A | — | 4 (best 0.71) |
| 5O2C | Crystal structure of WNK3 kinase and CCT1 didomain in a unphosphorylated state | x-ray diffraction | A | — | — |
| 9D7Q | Water and chloride as allosteric inhibitors in WNK kinase osmosensing | x-ray diffraction | A, B | — | 5 (best 0.69) |
| Q9BYP7 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK3 (Q9BYP7) | predicted | A | — | 8 (best 0.72) |
Ligands
Experiment against prediction
- 5O21 chain B against the predicted model Q9BYP7: TM-score 0.93, RMSD 1.94 Å
- 5O21 chain A against the predicted model Q9BYP7: TM-score 0.93, RMSD 1.91 Å
- 5O23 chain B against the predicted model Q9BYP7: TM-score 0.93, RMSD 2.07 Å
- 5O23 chain B against the predicted model Q9BYP7: TM-score 0.93, RMSD 2.07 Å
- 9D7Q chain B against the predicted model Q9BYP7: TM-score 0.93, RMSD 1.93 Å
- 5O23 chain A against the predicted model Q9BYP7: TM-score 0.93, RMSD 2.08 Å
- 5O23 chain A against the predicted model Q9BYP7: TM-score 0.93, RMSD 2.08 Å
- 9D7Q chain A against the predicted model Q9BYP7: TM-score 0.92, RMSD 1.86 Å
- 5O26 chain A against the predicted model Q9BYP7: TM-score 0.91, RMSD 2.14 Å
- 5O26 chain A against the predicted model Q9BYP7: TM-score 0.91, RMSD 2.14 Å
Elsewhere
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