MolNFT v1 · #499959 · protein

AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK3 (Q9BYP7)

Q9BYP7: “AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK3 (Q9BYP7)”. 8 pockets (best druggability 0.72). MolNFT v1 #499959 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q9BYP7
Type: protein
Length: 1,800 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x46EfCa788d03A3e879DAcDb96552AB8Bbc7e20b3
Molecule: SERINE/THREONINE-protein kinase WNK3
UniProt: Q9BYP7
Pockets: 8 · best druggability 0.72

Structure

1 distinct chain · 16% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase WNK3	protein	1800	16% helix, 6% strand	Q9BYP7

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	498	0.72	0.81	62	empty
2	173	0.57	0.81	33	empty
3	264	0.47	0.73	27	empty
4	97	0.43	0.78	18	empty
5	51	0.40	0.81	10	empty

Compared structures

5O2C · Crystal structure of WNK3 kinase and CCT1 didomain in a unphosphorylated state · an experimental structure of the same protein · chain A against A, TM-score 0.17
5O2C · Crystal structure of WNK3 kinase and CCT1 didomain in a unphosphorylated state · an experimental structure of the same protein · chain A against A, TM-score 0.17
5O23 · Crystal structure of WNK3 kinase domain in a monophosphorylated apo state · an experimental structure of the same protein · chain A against B, TM-score 0.15
5O23 · Crystal structure of WNK3 kinase domain in a monophosphorylated apo state · an experimental structure of the same protein · chain A against B, TM-score 0.15
5O21 · Crystal structure of WNK3 kinase domain in a monophosphorylated state with chloride bound… · an experimental structure of the same protein · chain A against B, TM-score 0.15
5O21 · Crystal structure of WNK3 kinase domain in a monophosphorylated state with chloride bound… · an experimental structure of the same protein · chain A against B, TM-score 0.15
5O1V · Crystal structure of WNK3 kinase domain in a monophosphorylated apo state (a-loop swapped) · an experimental structure of the same protein · chain A against A, TM-score 0.15
5O1V · Crystal structure of WNK3 kinase domain in a monophosphorylated apo state (A-loop swapped) · an experimental structure of the same protein · chain A against A, TM-score 0.15

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BYP7
Elsewhere: UniProt Q9BYP7 · AlphaFold DB Q9BYP7

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