MolNFT v1 · #128633 · protein
Insight into the molecular recognition mechanism of the coactivator NCOA1 by STAT6
5NWM · Nuclear receptor coactivator 1: “Insight into the molecular recognition mechanism of the coactivator NCOA1 by STAT6”. Solution nmr, 1 pocket (best druggability 0.56). MolNFT v1 #128633 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5NWM
- Type
- protein
- Length
- 164 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear receptor coactivator 1; Signal transducer and activator of transcription 6
- EC
- 2.3.1.48
- UniProt
- Q15788, P42226
- Pockets
- 1 · best druggability 0.56
Structure
solution nmr · 2 distinct chains · 25% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear receptor coactivator 1 (EC 2.3.1.48) | protein | 132 | 22% helix, 30% strand | Q15788 |
| B | Signal transducer and activator of transcription 6 | protein | 32 | 38% helix, 0% strand | P42226 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 188 | 0.56 | 0.80 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1039 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 5NWM · Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6 · the same entry in another collection · chain A against A, TM-score 1.00
- P42226 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription 6… · a predicted model of the same protein · chain B against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15788
- Every structure of UniProt P42226
- Elsewhere: RCSB PDB 5NWM · PDBe 5NWM · UniProt Q15788 · UniProt P42226
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