Research workbench
Insight into the molecular recognition mechanism of the coactivator NCOA1 by STAT6
Analyse Insight into the molecular recognition mechanism of the coactivator NCOA1 by… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5NWM
- Type
- protein
- Length
- 164 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear receptor coactivator 1; Signal transducer and activator of transcription 6
- EC
- 2.3.1.48
- UniProt
- Q15788, P42226
- Pockets
- 1 · best druggability 0.56
Structure
solution nmr · 2 distinct chains · 25% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear receptor coactivator 1 (EC 2.3.1.48) | protein | 132 | 22% helix, 30% strand | Q15788 |
| B | Signal transducer and activator of transcription 6 | protein | 32 | 38% helix, 0% strand | P42226 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 188 | 0.56 | 0.80 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1039 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 5NWM · Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6 · the same entry in another collection · chain A against A, TM-score 1.00
- P42226 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription 6… · a predicted model of the same protein · chain B against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15788
- Every structure of UniProt P42226
- Elsewhere: RCSB PDB 5NWM · PDBe 5NWM · UniProt Q15788 · UniProt P42226
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