UniProt P42226
Signal transducer and activator of transcription 6 (P42226)
Signal transducer and activator of transcription 6 (UniProt P42226): 13 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 36 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P42226
- Protein
- Signal transducer and activator of transcription 6
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 36 · 3 records with a druggable one
Structures
14 records of P42226 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OJ5 | Crystal structure of the Nco-A1 PAS-B domain bound to the STAT6 transactivation domain LXXLL motif | x-ray diffraction | B | — | — |
| 1OJ5 | Crystal structure of the nco-A1 pas-B domain bound to the STAT6 transactivation domain lxxll motif | x-ray diffraction | B | — | — |
| 4Y5U | Transcription factor | x-ray diffraction | A, B | — | — |
| 4Y5U | Transcription factor | x-ray diffraction | A, B | — | — |
| 4Y5W | Transcription factor-DNA complex | x-ray diffraction | A, B, D, C | — | — |
| 4Y5W | Transcription factor-DNA complex | x-ray diffraction | A, B, D, C | — | — |
| 5D39 | Transcription factor-DNA complex | x-ray diffraction | A, B, C, D | — | 20 (best 0.75) |
| 5D39 | Transcription factor-DNA complex | x-ray diffraction | A, B, C, D | — | — |
| 5NWM | Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6 | solution nmr | B | — | — |
| 5NWM | Insight into the molecular recognition mechanism of the coactivator NCOA1 by STAT6 | solution nmr | B | — | — |
| 5NWX | Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6 | x-ray diffraction | B | — | — |
| 5NWX | Insight into the molecular recognition mechanism of the coactivator NCOA1 by STAT6 | x-ray diffraction | B | — | — |
| 9BIG | Stat6 bound to degrader AK-1690 | x-ray diffraction | A | A1AQQ | 5 (best 0.64) |
| P42226 | AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription 6 (P42226) | predicted | A | — | 11 (best 0.69) |
Ligands
- A1AQQ · [(2-{[(2S)-1-{(2S,4S)-4-[(7-{2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}hept-6-yn-1-yl)oxy]-2-[(2R)-2-phenylmorpholine-4-carbonyl]pyrrolidin-1-yl}-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-1-benzothiophen-5-yl)di(fluoro)methyl]phosphonic acid · in 1 record
Experiment against prediction
- 4Y5W chain A against the predicted model P42226: TM-score 0.99, RMSD 0.88 Å
- 4Y5W chain A against the predicted model P42226: TM-score 0.99, RMSD 0.88 Å
- 5D39 chain A against the predicted model P42226: TM-score 0.99, RMSD 0.89 Å
- 5D39 chain A against the predicted model P42226: TM-score 0.99, RMSD 0.89 Å
- 4Y5W chain B against the predicted model P42226: TM-score 0.99, RMSD 0.89 Å
- 4Y5W chain B against the predicted model P42226: TM-score 0.99, RMSD 0.89 Å
- 5D39 chain B against the predicted model P42226: TM-score 0.99, RMSD 0.93 Å
- 5D39 chain B against the predicted model P42226: TM-score 0.99, RMSD 0.93 Å
- 4Y5W chain D against the predicted model P42226: TM-score 0.98, RMSD 1.16 Å
- 4Y5W chain D against the predicted model P42226: TM-score 0.98, RMSD 1.16 Å
Elsewhere
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