Crystal structure of the GLUA2 ligand-binding domain (S1S2J) in complex with agonist cip-as at 1.15 a resolution.

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).

Ligands and binding sites

• 8VN · (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid · ligand · chains A
• 8WQ · (2~{S},3~{R},4~{R})-3-(carboxycarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylic acid · ligand · chains A
• LI · Lithium ion · metal · chains A
• SO4 · Sulfate ion · ion · 3 copies · chains A
• FLC · Citrate anion · additive · 2 copies · chains A
• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 5NG9 · Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P19491
• Elsewhere: RCSB PDB 5NG9 · PDBe 5NG9 · UniProt P19491