Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ3451 at 3.6 ångström resolution

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• 8UN · 2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide · ligand · chains A
• NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5NDZ · Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in… · the same entry in another collection · chain A against A, TM-score 1.00
• P55085 · AlphaFold monomer V2.0 prediction for proteinase-activated receptor 2 (P55085) · a predicted model of the same protein · chain A against A, TM-score 0.55
• P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain A against A, TM-score 0.20

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt D9IEF7
• Every structure of UniProt P55085
• Every structure of UniProt P0ABE7
• Elsewhere: RCSB PDB 5NDZ · PDBe 5NDZ · UniProt D9IEF7 · UniProt P55085 · UniProt P0ABE7