MolNFT v1 · #127430 · protein

Human notch-2 EGF11-13

5MWB · Neurogenic locus notch homolog protein 2: “Human notch-2 EGF11-13”. X-ray diffraction, 4 ligands (BGC, XYP, FUC). MolNFT v1 #127430 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5MWB
Type: protein
Length: 118 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurogenic locus notch homolog protein 2
UniProt: Q04721
Ligands: BGC, XYP, FUC, CA

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neurogenic locus notch homolog protein 2	protein	118	7% helix, 34% strand	Q04721

Ligands and binding sites

BGC · beta-D-glucopyranose · sugar · 2 copies · chains A
XYP · beta-D-xylopyranose · sugar · chains A
FUC · alpha-L-fucopyranose · sugar · chains A
CA · Calcium ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 9 disulfide, 3 glycan (disulfide, O-glycosylation).

Compared structures

5MWB · Human Notch-2 EGF11-13 · the same entry in another collection · chain A against A, TM-score 1.00
Q04721 · AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 2 (Q04721) · a predicted model of the same protein · chain A against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q04721
Elsewhere: RCSB PDB 5MWB · PDBe 5MWB · UniProt Q04721

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