MolNFT v1 · #12712 · protein
Pkci-1-APO+ZINC
1KPC · Human protein kinase C interacting protein 1 (zinc protein): “Pkci-1-APO+ZINC”. X-ray diffraction, 5 pockets (best druggability 0.56). MolNFT v1 #12712 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1KPC
- Type
- protein
- Length
- 442 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human protein kinase C interacting protein 1 (zinc protein)
- UniProt
- P49773
- Pockets
- 5 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Human protein kinase C interacting protein 1 (zinc protein) | protein | 111 | 31% helix, 26% strand | P49773 |
| D | Human protein kinase C interacting protein 1 (zinc protein) | protein | 109 | 29% helix, 26% strand | P49773 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 295 | 0.56 | 0.76 | 50 | empty |
| 2 | 92 | 0.53 | 0.84 | 29 | empty |
| 3 | 70 | 0.37 | 0.77 | 21 | empty |
| 4 | 80 | 0.35 | 0.75 | 26 | empty |
| 5 | 66 | 0.32 | 0.75 | 21 | empty |
Interfaces
5 interfaces between chains.
- C–D · 2034 Ų buried · 47 hydrogen bonds · protein-protein
- A–B · 2027 Ų buried · 48 hydrogen bonds · protein-protein
- B–C · 393 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 155 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 56 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1KPC · Pkci-1-APO+ZINC · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49773
- Elsewhere: RCSB PDB 1KPC · PDBe 1KPC · UniProt P49773
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