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Pkci-1-APO+ZINC

Analyse Pkci-1-APO+ZINC in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1KPC
Type: protein
Length: 442 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human protein kinase C interacting protein 1 (zinc protein)
UniProt: P49773
Pockets: 5 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Human protein kinase C interacting protein 1 (zinc protein)	protein	111	31% helix, 26% strand	P49773
D	Human protein kinase C interacting protein 1 (zinc protein)	protein	109	29% helix, 26% strand	P49773

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	295	0.56	0.76	50	empty
2	92	0.53	0.84	29	empty
3	70	0.37	0.77	21	empty
4	80	0.35	0.75	26	empty
5	66	0.32	0.75	21	empty

Interfaces

5 interfaces between chains.

C–D · 2034 Å² buried · 47 hydrogen bonds · protein-protein
A–B · 2027 Å² buried · 48 hydrogen bonds · protein-protein
B–C · 393 Å² buried · 3 hydrogen bonds · protein-protein
B–D · 155 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 56 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1KPC · Pkci-1-APO+ZINC · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49773
Elsewhere: RCSB PDB 1KPC · PDBe 1KPC · UniProt P49773

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