UniProt P49773
Histidine triad nucleotide-binding protein 1 (P49773)
Histidine triad nucleotide-binding protein 1 (UniProt P49773), EC 3.-.-.-: 86 experimental structures on GenesisL1, 33 ligands bound, 29 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P49773
- Protein
- Histidine triad nucleotide-binding protein 1
- EC
- 3.-.-.-
- Experimental structures
- 86
- Predicted models
- 0
- Ligands
- 33
- Pockets
- 29 · 1 record with a druggable one
Structures
86 records of P49773 in the MolNFT archive: 86 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AV5 | Pkci-substrate analog | x-ray diffraction | A, B | — | — |
| 1AV5 | Pkci-substrate analog | x-ray diffraction | A, B | — | — |
| 1KPA | PKCI-1-ZINC | x-ray diffraction | A, B | — | — |
| 1KPA | PKCI-1-ZINC | x-ray diffraction | A, B | — | — |
| 1KPB | PKCI-1-APO | x-ray diffraction | A, B | — | — |
| 1KPB | PKCI-1-APO | x-ray diffraction | A, B | — | — |
| 1KPC | Pkci-1-APO+ZINC | x-ray diffraction | A, B, C, D | — | — |
| 1KPC | Pkci-1-APO+ZINC | x-ray diffraction | A, B, C, D | — | — |
| 1KPE | Pkci-transition state analog | x-ray diffraction | A, B | — | — |
| 1KPE | Pkci-transition state analog | x-ray diffraction | A, B | — | — |
| 1KPF | Pkci-substrate analog | x-ray diffraction | A | — | — |
| 1KPF | Pkci-substrate analog | x-ray diffraction | A | — | — |
| 3TW2 | High resolution structure of human histidine triad nucleotide-binding protein 1 (hHINT1)/AMP… | x-ray diffraction | A, B | — | — |
| 3TW2 | High resolution structure of human histidine triad nucleotide-binding protein 1 (HHINT1)/AMP… | x-ray diffraction | A, B | — | — |
| 4EQE | Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with… | x-ray diffraction | A, B | — | — |
| 4EQE | Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with… | x-ray diffraction | A, B | — | — |
| 4EQG | Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with… | x-ray diffraction | A, B | — | — |
| 4EQG | Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with… | x-ray diffraction | A, B | — | — |
| 4EQH | Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with… | x-ray diffraction | A, B | — | — |
| 4EQH | Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with… | x-ray diffraction | A, B | — | — |
| 4ZKL | Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with… | x-ray diffraction | A, B, C, D | — | — |
| 4ZKL | Crystal structure of human histidine triad nucleotide-binding protein 1 (HHINT1) complexed with… | x-ray diffraction | A, B, C, D | — | — |
| 4ZKV | Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) refined to 1.92A… | x-ray diffraction | A, B, C, D | — | — |
| 4ZKV | Crystal structure of human histidine triad nucleotide-binding protein 1 (HHINT1) refined to 1.92A… | x-ray diffraction | A, B, C, D | — | — |
| 5ED3 | crystal structure of human Hint1 complexing with AP5A | x-ray diffraction | A, B | AMP | — |
| 5ED3 | Crystal structure of human HINT1 complexing with AP5A | x-ray diffraction | A, B | — | — |
| 5ED6 | crystal structure of human Hint1 H114A mutant complexing with ATP | x-ray diffraction | A, B | AMP | — |
| 5ED6 | Crystal structure of human HINT1 H114A mutant complexing with ATP | x-ray diffraction | A, B | — | — |
| 5EMT | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)-copper complex | x-ray diffraction | A, B | CU | — |
| 5EMT | Human histidine triad nucleotide binding protein 1 (HHINT1)-copper complex | x-ray diffraction | A, B | — | — |
| 5I2E | Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound Sulfamate Inhibitor… | x-ray diffraction | A, B | 67D | — |
| 5I2E | Human histidine triad nucleotide binding protein 1 (HINT1) with bound sulfamate inhibitor… | x-ray diffraction | A, B | — | — |
| 5I2F | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) with bound sulfamide inhibitor Bio-AMS | x-ray diffraction | B, A | BS5 | 2 (best 0.38) |
| 5I2F | Human histidine triad nucleotide binding protein 1 (HHINT1) with bound sulfamide inhibitor bio-ams | x-ray diffraction | B, A | — | — |
| 5IPB | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant | x-ray diffraction | A, B | CL | — |
| 5IPB | Human histidine triad nucleotide binding protein 1 (HHINT1) H112N mutant | x-ray diffraction | A, B | — | — |
| 5IPC | Human histidine triad nucleotide binding protein 1 (HHINT1) H112N mutant nucleoside… | x-ray diffraction | A, B | — | — |
| 5IPD | Human histidine triad nucleotide binding protein 1 (HHINT1) nucleoside thiophosphoramidate covalent… | x-ray diffraction | A, B | — | — |
| 5IPE | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) nucleoside thiophosphoramidate… | x-ray diffraction | A, B | 6CG, CL | — |
| 5IPE | Human histidine triad nucleotide binding protein 1 (HHINT1) nucleoside thiophosphoramidate… | x-ray diffraction | A, B | — | — |
| 5KLY | Human histidine triad nucleotide binding protein 1 (HHINT1) H112N mutant adenosine nucleoside… | x-ray diffraction | A, B | 6UR, CL | — |
| 5KLZ | Human histidine triad nucleotide binding protein 1 (HHINT1) AMP catalytic product complex | x-ray diffraction | B, A | AMP | — |
| 5KM0 | Human Histidine Triad Nucleotide Binding Protein 1 (hHint) IMP complex | x-ray diffraction | B, A, C, D | IMP | — |
| 5KM0 | Human histidine triad nucleotide binding protein 1 (hhint) imp complex | x-ray diffraction | B, A, C, D | IMP | — |
| 5KM1 | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) GMP catalytic product complex | x-ray diffraction | A, B | 5GP | 2 (best 0.36) |
| 5KM1 | Human histidine triad nucleotide binding protein 1 (HHINT1) gmp catalytic product complex | x-ray diffraction | A, B | 5GP | — |
| 5KM2 | Human histidine triad nucleotide binding protein 1 (HHINT1) cmp catalytic product complex | x-ray diffraction | A, B | C5P, CL | — |
| 5KM3 | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) UMP catalytic product complex | x-ray diffraction | A, B | U5P | — |
| 5KM3 | Human histidine triad nucleotide binding protein 1 (HHINT1) ump catalytic product complex | x-ray diffraction | A, B | U5P | — |
| 5KM4 | Human histidine triad nucleotide binding protein 1 (HHINT1)-5-iodo-ump complex | x-ray diffraction | A, B | IU | — |
| 5KM6 | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant Ara-A nucleoside… | x-ray diffraction | A | 6US | — |
| 5KM6 | Human histidine triad nucleotide binding protein 1 (HHINT1) H112N mutant ara-a nucleoside… | x-ray diffraction | A | 6US | — |
| 5KMA | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Trp… | x-ray diffraction | A, B | 777, CL | — |
| 5KMA | Human histidine triad nucleotide binding protein 1 (HHINT1) H112N mutant nucleoside D-TRP… | x-ray diffraction | A, B | 777, CL | — |
| 5KMB | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside L-Trp… | x-ray diffraction | A, B | 6UT, CL | — |
| 5KMB | Human histidine triad nucleotide binding protein 1 (HHINT1) H112N mutant nucleoside L-TRP… | x-ray diffraction | A, B | 6UT, CL | — |
| 5KMC | Human histidine triad nucleotide binding protein 1 (HHINT1) non- nucleotidic covalent intermediate… | x-ray diffraction | A, B | 6UU | — |
| 5O8I | Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) crystallized at… | x-ray diffraction | A, B | ADP | 2 (best 0.37) |
| 5O8I | Crystal structure of human histidine triad nucleotide-binding protein 1 (HHINT1) crystallized at… | x-ray diffraction | A, B | ADP | — |
| 5WA8 | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside L-Ala… | x-ray diffraction | A, B | 9ZA, CL | — |
26 records more on the page itself.
Ligands
- CL · Chloride ion · in 18 records
- AMP · Adenosine monophosphate · in 5 records
- B4P · Bis(adenosine)-5'-tetraphosphate · in 4 records
- ESA · Ethanesulfonic acid · in 4 records
- 5GP · Guanosine-5'-monophosphate · in 2 records
- 6US · [(2~{R},3~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[2-(1~{H}-indol-3-yl)ethyl]phosphonamidic acid · in 2 records
- 6UT · [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]phosphonamidic acid · in 2 records
- 777 · [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-ethyl-phosphonamidic acid · in 2 records
- 9ZA · [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{S})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid · in 2 records
- 9ZD · [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{R})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid · in 2 records
- ADN · Adenosine · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- AP5 · Bis(adenosine)-5'-pentaphosphate · in 2 records
- IMP · Inosinic acid · in 2 records
- KBD · 5'-O-(benzylcarbamoyl)guanosine · in 2 records
- TAU · 2-aminoethanesulfonic acid · in 2 records
- U5P · Uridine-5'-monophosphate · in 2 records
- 67D · 3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine · in 1 record
- 6CG · 5'-S-phosphono-5'-thioguanosine · in 1 record
- 6UR · [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[2-(1~{H}-indol-3-yl)ethyl]phosphonamidic acid · in 1 record
- 6UU · [2-(1~{H}-indol-3-yl)ethylamino]phosphonic acid · in 1 record
- BS5 · 5'-deoxy-5'-[({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)amino]adenosine · in 1 record
- C5P · Cytidine-5'-monophosphate · in 1 record
- CU · Copper (II) ion · in 1 record
- D5M · 2'-deoxyadenosine-5'-monophosphate · in 1 record
- HHJ · 5'-O-{[2-(1H-indol-3-yl)ethyl]carbamoyl}guanosine · in 1 record
- IU · 5-iodouridine-5'-monophosphate · in 1 record
- KB7 · 5'-O-(ethylcarbamoyl)guanosine · in 1 record
- KBJ · 5'-O-[(2-phenylethyl)carbamoyl]guanosine · in 1 record
- LMR · (2S)-2-hydroxybutanedioic acid · in 1 record
Elsewhere
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