MolNFT v1 · #127061 · protein
Plantago major multifunctional oxidoreductase in complex with 8- oxogeranial and NADP+
5MLH · Progesterone 5-beta-reductase: “Plantago major multifunctional oxidoreductase in complex with 8- oxogeranial and NADP+”. X-ray diffraction, 4 ligands (XOG, NAP, NA), 1 pocket (best druggability 0.83). MolNFT v1 #127061 on GenesisL1…
- PDB
- 5MLH
- Type
- protein
- Length
- 364 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Progesterone 5-beta-reductase
- EC
- 1.1.1.145
- UniProt
- D6N9X1
- Ligands
- XOG, NAP, NA, CA
- Pockets
- 1 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Progesterone 5-beta-reductase (EC 1.1.1.145) | protein | 364 | 42% helix, 13% strand | D6N9X1 |
Ligands and binding sites
- XOG · (2E,6E)-2,6-dimethylocta-2,6-dienedial · ligand · chains A
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- NA · Sodium ion · metal · chains A
- CA · Calcium ion · metal · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 446 | 0.83 | 0.90 | 61 | XOG, NAP, CA |
Compared structures
- 5MLH · Plantago Major multifunctional oxidoreductase in complex with 8-oxogeranial and NADP+ · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D6N9X1
- Elsewhere: RCSB PDB 5MLH · PDBe 5MLH · UniProt D6N9X1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.