MolNFT v1 · #126928 · protein

Fxiiia in complex with the inhibitor ZED2360

5MHN: “Fxiiia in complex with the inhibitor ZED2360”. X-ray diffraction, 4 ligands (7NF, 1TX, CA). MolNFT v1 #126928 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5MHN
Type: protein
Length: 1,385 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P00488
Ligands: 7NF, 1TX, CA, SO4

Structure

x-ray diffraction · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	688	—	P00488
B	—	protein	685	—	P00488
H, I	—	protein	6	—	—

Ligands and binding sites

7NF · 2-ethoxycarbonyl-1,3-thiazole-4-carboxylic acid · ligand · 2 copies · chains A, H, B, I
1TX · (2S)-2-amino-7-methoxy-7-oxoheptanoic acid · ligand · 2 copies · chains A, H, B, I
CA · Calcium ion · metal · 6 copies · chains A, B
SO4 · Sulfate ion · ion · 5 copies · chains A, B
GOL · Glycerol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5MHN · FXIIIa in complex with the inhibitor ZED2360 · the same entry in another collection · chain A against A, TM-score 1.00
P00488 · AlphaFold monomer V2.0 prediction for coagulation factor xiii a chain (P00488) · a predicted model of the same protein · chain B against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00488
Elsewhere: RCSB PDB 5MHN · PDBe 5MHN · UniProt P00488

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