UniProt P00488
Coagulation factor XIII A chain (P00488)
Coagulation factor XIII A chain (UniProt P00488), EC 2.3.2.13: 27 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 64 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P00488
- Protein
- Coagulation factor XIII A chain
- EC
- 2.3.2.13
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 64 · 5 records with a druggable one
Structures
28 records of P00488 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EVU | Human factor xiii with calcium bound in the ion site | x-ray diffraction | A, B | — | — |
| 1EVU | Human factor xiii with calcium bound in the ion site | x-ray diffraction | A, B | — | — |
| 1EX0 | Human factor xiii, mutant W279F zymogen | x-ray diffraction | A, B | — | — |
| 1EX0 | Human factor xiii, mutant W279F zymogen | x-ray diffraction | A, B | — | — |
| 1F13 | Recombinant human cellular coagulation factor xiii | x-ray diffraction | A, B | — | — |
| 1F13 | Recombinant human cellular coagulation factor xiii | x-ray diffraction | A, B | — | — |
| 1FIE | Recombinant human coagulation factor xiii | x-ray diffraction | A, B | — | — |
| 1FIE | Recombinant human coagulation factor xiii | x-ray diffraction | A, B | — | — |
| 1GGT | Three-dimensional structure of a transglutaminase: human blood coagulation factor xiii | x-ray diffraction | A, B | — | — |
| 1GGT | Three-dimensional structure of a transglutaminase: human blood coagulation factor xiii | x-ray diffraction | A, B | — | — |
| 1GGU | Human factor xiii with calcium bound in the ion site | x-ray diffraction | A, B | — | — |
| 1GGU | Human factor xiii with calcium bound in the ion site | x-ray diffraction | A, B | — | — |
| 1GGY | Human factor xiii with ytterbium bound in the ion site | x-ray diffraction | A, B | — | — |
| 1GGY | Human factor xiii with ytterbium bound in the ion site | x-ray diffraction | A, B | — | — |
| 1QRK | Human factor xiii with strontium bound in the ion site | x-ray diffraction | A, B | — | — |
| 1QRK | Human factor xiii with strontium bound in the ion site | x-ray diffraction | A, B | — | — |
| 4KTY | Fibrin-stabilizing factor with a bound ligand | x-ray diffraction | A, B | — | — |
| 4KTY | Fibrin-stabilizing factor with a bound ligand | x-ray diffraction | A, B | — | — |
| 5MHL | Fxiiia in complex with the inhibitor MI0621 | x-ray diffraction | A, B | 7NX, NH2, CA, SO4 | — |
| 5MHM | FXIIIa in complex with the inhibitor ZED1630 | x-ray diffraction | A, B | CA, CL, SO4 | 8 (best 0.63) |
| 5MHM | Fxiiia in complex with the inhibitor ZED1630 | x-ray diffraction | A, B | 7NW, 1TX, NH2, CA, CL, SO4 | — |
| 5MHN | FXIIIa in complex with the inhibitor ZED2360 | x-ray diffraction | A, B | CA, SO4 | 9 (best 0.61) |
| 5MHN | Fxiiia in complex with the inhibitor ZED2360 | x-ray diffraction | A, B | 7NF, 1TX, CA, SO4 | — |
| 5MHO | FXIIIa in complex with the inhibitor ZED2369 | x-ray diffraction | A, B | CA, SO4 | 9 (best 0.64) |
| 5MHO | Fxiiia in complex with the inhibitor ZED2369 | x-ray diffraction | A, B | TRM, 1TX, NH2, CA, SO4 | — |
| 8CMT | Structure of the plasma coagulation Factor XIII A2B2 heterotetrameric complex. | electron microscopy | A, B | — | 18 (best 0.83) |
| 8CMU | High resolution structure of the coagulation Factor XIII A2B2 heterotetramer complex. | electron microscopy | A, B | — | 20 (best 0.78) |
| P00488 | AlphaFold monomer V2.0 prediction for coagulation factor xiii a chain (P00488) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 7 records
- SO4 · Sulfate ion · in 7 records
- 1TX · (2S)-2-amino-7-methoxy-7-oxoheptanoic acid · in 3 records
- NH2 · Amino group · in 3 records
- CL · Chloride ion · in 2 records
- 7NF · 2-ethoxycarbonyl-1,3-thiazole-4-carboxylic acid · in 1 record
- 7NW · 2-methyl-1,3-thiazole-4-carboxylic acid · in 1 record
- 7NX · Cyclohexylmethyl hydrogen carbonate · in 1 record
- TRM · 1H-benoximidazole-2-carboxylic acid · in 1 record
Experiment against prediction
- 8CMU chain A against the predicted model P00488: TM-score 0.99, RMSD 0.72 Å
- 1F13 chain A against the predicted model P00488: TM-score 0.99, RMSD 0.74 Å
- 1F13 chain A against the predicted model P00488: TM-score 0.99, RMSD 0.74 Å
- 8CMU chain B against the predicted model P00488: TM-score 0.99, RMSD 0.74 Å
- 1QRK chain B against the predicted model P00488: TM-score 0.99, RMSD 0.74 Å
- 1QRK chain B against the predicted model P00488: TM-score 0.99, RMSD 0.74 Å
- 8CMT chain A against the predicted model P00488: TM-score 0.99, RMSD 0.75 Å
- 1F13 chain B against the predicted model P00488: TM-score 0.99, RMSD 0.77 Å
- 1F13 chain B against the predicted model P00488: TM-score 0.99, RMSD 0.77 Å
- 1GGY chain B against the predicted model P00488: TM-score 0.99, RMSD 0.77 Å
Elsewhere
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