MolNFT v1 · #126667 · protein
Human angiogenin als variant F100I
5M9R: “Human angiogenin als variant F100I”. X-ray diffraction, 1 pocket (best druggability 0.68). MolNFT v1 #126667 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5M9R
- Type
- protein
- Length
- 243 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Angiogenin
- EC
- 3.1.27.-
- UniProt
- P03950
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Angiogenin (EC 3.1.27.-) | protein | 122 | 27% helix, 34% strand | P03950 |
| B | Angiogenin (EC 3.1.27.-) | protein | 121 | 26% helix, 35% strand | P03950 |
Ligands and binding sites
- TAR · D(-)-tartaric acid · additive · 2 copies · chains A, B
- TLA · L(+)-tartaric acid · additive · 2 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 317 | 0.68 | 0.83 | 45 | TAR, TLA |
Interfaces
1 interface between chains.
- A–B · 662 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03950
- Elsewhere: RCSB PDB 5M9R · PDBe 5M9R · UniProt P03950
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