MolNFT v1 · #126570 · protein

Human PI3KDELTA in complex with LASW1579

5M6U: “Human PI3KDELTA in complex with LASW1579”. X-ray diffraction, 1 ligand (7KA). MolNFT v1 #126570 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5M6U
Type: protein
Length: 1,080 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O00329, P27986
Ligands: 7KA

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	916	—	O00329
B	—	protein	164	—	P27986

Ligands and binding sites

7KA · 4-azanyl-6-[[(1~{S})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl) ethyl]amino]pyrimidine-5-carbonitrile · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5M6U · Human PI3KDELTA in complex with LASW1579 · the same entry in another collection · chain A against A, TM-score 1.00
O00329 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00329
Every structure of UniProt P27986
Elsewhere: RCSB PDB 5M6U · PDBe 5M6U · UniProt O00329 · UniProt P27986

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