MolNFT v1 · #126531 · protein
S. cerevisiae spliceosomal helicase BRR2 (271-end) in complex with the JAB/MPN domain of S. cerevisiae PRP8
5M5P · Pre-mRNA-splicing helicase BRR2: “S. cerevisiae spliceosomal helicase BRR2 (271-end) in complex with the JAB/MPN domain of S. cerevisiae PRP8”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #126531 on GenesisL1…
- PDB
- 5M5P
- Type
- protein
- Length
- 4,196 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-mRNA-splicing helicase BRR2; Pre-mRNA-splicing factor 8
- EC
- 3.6.4.13
- UniProt
- P32639, P33334
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 3 distinct chains · 42% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pre-mRNA-splicing helicase BRR2 (EC 3.6.4.13) | protein | 1850 | 44% helix, 16% strand | P32639 |
| B, D | Pre-mRNA-splicing factor 8 | protein | 248 | 22% helix, 28% strand | P33334 |
| C | Pre-mRNA-splicing helicase BRR2 (EC 3.6.4.13) | protein | 1850 | 44% helix, 16% strand | P32639 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 946 | 0.84 | 0.85 | 110 | empty |
| 2 | 855 | 0.84 | 0.86 | 81 | empty |
| 3 | 747 | 0.83 | 0.86 | 82 | empty |
| 4 | 1101 | 0.82 | 0.83 | 138 | empty |
| 5 | 1054 | 0.82 | 0.83 | 115 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1679 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1653 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 129 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5M5P · S. cerevisiae spliceosomal helicase Brr2 (271-end) in complex with the Jab/MPN domain of… · the same entry in another collection · chain D against D, TM-score 1.00
- P32639 · AlphaFold monomer V2.0 prediction for pre-mRNA-splicing helicase BRR2 (P32639) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32639
- Every structure of UniProt P33334
- Elsewhere: RCSB PDB 5M5P · PDBe 5M5P · UniProt P32639 · UniProt P33334
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