UniProt P32639
Pre-mRNA-splicing helicase BRR2 (P32639)
Pre-mRNA-splicing helicase BRR2 (UniProt P32639), EC 3.6.1.-, 3.6.4.13: 31 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 160 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P32639
- Protein
- Pre-mRNA-splicing helicase BRR2
- EC
- 3.6.1.-, 3.6.4.13
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 160 · 13 records with a druggable one
Structures
32 records of P32639 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3HIB | Crystal structure of the second Sec63 domain of yeast Brr2 | x-ray diffraction | A | — | 4 (best 0.37) |
| 3HIB | Crystal structure of the second SEC63 domain of yeast BRR2 | x-ray diffraction | A | — | 4 (best 0.37) |
| 3IM1 | Structure of the C-terminal Sec63 unit of yeast Brr2, P212121 Form | x-ray diffraction | A | — | 3 (best 0.49) |
| 3IM1 | Structure of the C-terminal SEC63 unit of yeast BRR2, P212121 form | x-ray diffraction | A | — | 3 (best 0.49) |
| 3IM2 | Structure of the C-terminal Sec63 unit of yeast Brr2, P41212 Form | x-ray diffraction | A | — | 4 (best 0.38) |
| 3IM2 | Structure of the C-terminal SEC63 unit of yeast BRR2, P41212 form | x-ray diffraction | A | — | 4 (best 0.38) |
| 3JCM | Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP | electron microscopy | N | — | — |
| 3JCM | Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snrnp | electron microscopy | N | — | — |
| 4BGD | Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8 | x-ray diffraction | A | ADP, MG | 19 (best 0.84) |
| 4BGD | Crystal structure of BRR2 in complex with the JAB1/MPN domain of PRP8 | x-ray diffraction | A | ADP, MG | 19 (best 0.84) |
| 5DCA | Crystal structure of yeast full length Brr2 in complex with Prp8 Jab1 domain | x-ray diffraction | A | — | 20 (best 0.86) |
| 5DCA | Crystal structure of yeast full length BRR2 in complex with PRP8 JAB1 domain | x-ray diffraction | A | — | — |
| 5GAN | The overall structure of the yeast spliceosomal U4/U6.U5 tri-snrnp at 3.7 ångström | electron microscopy | B | — | — |
| 5GAO | Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP | electron microscopy | B | — | 13 (best 0.84) |
| 5GAO | Head region of the yeast spliceosomal U4/U6.U5 tri-snrnp | electron microscopy | B | — | — |
| 5GAP | Body region of the U4/U6.U5 tri-snRNP | electron microscopy | B | — | 1 (best 0.70) |
| 5GAP | Body region of the U4/U6.U5 tri-snrnp | electron microscopy | B | — | — |
| 5GM6 | Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution | electron microscopy | B | — | 4 (best 0.86) |
| 5LJ5 | Overall structure of the yeast spliceosome immediately after branching. | electron microscopy | B | — | 4 (best 0.84) |
| 5LJ5 | Overall structure of the yeast spliceosome immediately after branching. | electron microscopy | B | — | — |
| 5LQW | yeast activated spliceosome | electron microscopy | C | — | — |
| 5LQW | Yeast activated spliceosome | electron microscopy | C | — | — |
| 5M52 | Crystal structure of yeast Brr2 full-lenght in complex with Prp8 Jab1 domain | x-ray diffraction | A, B | — | 20 (best 0.86) |
| 5M52 | Crystal structure of yeast BRR2 full-lenght in complex with PRP8 JAB1 domain | x-ray diffraction | A, B | — | — |
| 5M5P | S. cerevisiae spliceosomal helicase Brr2 (271-end) in complex with the Jab/MPN domain of S.… | x-ray diffraction | A, C | — | 20 (best 0.84) |
| 5M5P | S. cerevisiae spliceosomal helicase BRR2 (271-end) in complex with the JAB/MPN domain of S.… | x-ray diffraction | A, C | — | — |
| 5NRL | Structure of a pre-catalytic spliceosome | electron microscopy | B | — | 5 (best 0.86) |
| 5ZWM | Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom… | electron microscopy | D | — | 5 (best 0.88) |
| 5ZWO | Cryo-EM structure of the yeast B complex at average resolution of 3.9 angstrom | electron microscopy | D | — | 5 (best 0.83) |
| 5ZWO | Cryo-EM structure of the yeast B complex at average resolution of 3.9 ångström | electron microscopy | D | — | — |
| 7B9V | Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound | electron microscopy | B | — | 3 (best 0.85) |
| P32639 | AlphaFold monomer V2.0 prediction for pre-mRNA-splicing helicase BRR2 (P32639) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4BGD chain A against the predicted model P32639: TM-score 0.99, RMSD 1.38 Å
- 4BGD chain A against the predicted model P32639: TM-score 0.99, RMSD 1.38 Å
- 5LJ5 chain B against the predicted model P32639: TM-score 0.99, RMSD 1.38 Å
- 5LJ5 chain B against the predicted model P32639: TM-score 0.99, RMSD 1.38 Å
- 5DCA chain A against the predicted model P32639: TM-score 0.99, RMSD 1.57 Å
- 5DCA chain A against the predicted model P32639: TM-score 0.99, RMSD 1.57 Å
- 3HIB chain A against the predicted model P32639: TM-score 0.98, RMSD 0.96 Å
- 3HIB chain A against the predicted model P32639: TM-score 0.98, RMSD 0.96 Å
- 5M52 chain A against the predicted model P32639: TM-score 0.98, RMSD 2.01 Å
- 5M52 chain A against the predicted model P32639: TM-score 0.98, RMSD 2.01 Å
Elsewhere
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