MolNFT v1 · #126333 · protein

Binding of the C-terminal gqyl motif of the bacterial proteasome activator bpa to the 20S proteasome

5LZP · Proteasome subunit alpha: “Binding of the C-terminal gqyl motif of the bacterial proteasome activator bpa to the 20S proteasome”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #126333 on GenesisL1: 3D…

PDB: 5LZP
Type: protein
Length: 6,182 residues
Chains: 35
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proteasome subunit alpha; Bacterial proteasome activator; Proteasome subunit beta
EC: 3.4.25.1
UniProt: P9WHU1, P9WKX3, P9WHT9
Pockets: 20 · best druggability 0.86

Structure

electron microscopy · 7 distinct chains · 42% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
0, 2, 4, 6, 8, H, J, S, W, Y	Proteasome subunit alpha (EC 3.4.25.1)	protein	215	42% helix, 26% strand	P9WHU1
1, 3, 5, 7, V, X, Z	Bacterial proteasome activator	protein	5	0% helix, 20% strand	P9WKX3
A, E, F, G, K, L	Proteasome subunit beta (EC 3.4.25.1)	protein	222	41% helix, 29% strand	P9WHT9
B, M, Q	Proteasome subunit alpha (EC 3.4.25.1)	protein	214	43% helix, 26% strand	P9WHU1
C, I, O, R, T, U	Proteasome subunit beta (EC 3.4.25.1)	protein	223	41% helix, 30% strand	P9WHT9
D	Proteasome subunit alpha (EC 3.4.25.1)	protein	217	42% helix, 25% strand	P9WHU1
N, P	Proteasome subunit beta (EC 3.4.25.1)	protein	234	41% helix, 29% strand	P9WHT9

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1181	0.86	0.87	114	empty
2	611	0.84	0.89	47	empty
3	584	0.84	0.89	50	empty
4	607	0.84	0.89	50	empty
5	579	0.84	0.89	45	empty

Interfaces

84 interfaces between chains.

G–N · 804 Å² buried · 14 hydrogen bonds · protein-protein
E–P · 789 Å² buried · 14 hydrogen bonds · protein-protein
K–L · 755 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 755 Å² buried · 14 hydrogen bonds · protein-protein
F–I · 754 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

5LZP · Binding of the C-terminal GQYL motif of the bacterial proteasome activator Bpa to the 20S… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WHU1
Every structure of UniProt P9WKX3
Every structure of UniProt P9WHT9
Elsewhere: RCSB PDB 5LZP · PDBe 5LZP · UniProt P9WHU1 · UniProt P9WKX3 · UniProt P9WHT9

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