UniProt P9WHT9
Proteasome subunit beta (P9WHT9)
Proteasome subunit beta (UniProt P9WHT9), EC 3.4.25.1: 7 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 54 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P9WHT9
- Protein
- Proteasome subunit beta
- EC
- 3.4.25.1
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 54 · 3 records with a druggable one
Structures
8 records of P9WHT9 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LZP | Binding of the C-terminal GQYL motif of the bacterial proteasome activator Bpa to the 20S proteasome | electron microscopy | A, C, E, F, G, I, K, L, N, O, P, R, T, U | — | 20 (best 0.86) |
| 5LZP | Binding of the C-terminal gqyl motif of the bacterial proteasome activator bpa to the 20S proteasome | electron microscopy | A, C, E, F, G, I, K, L, N, O, P, R, T, U | — | — |
| 6OCW | Crystal structure of mycobacterium tuberculosis proteasome in complex with phenylimidazole-based… | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | M6M | — |
| 6OCZ | Crystal structure of mycobacterium tuberculosis proteasome in complex with phenylimidazole-based… | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | M6Y | — |
| 6ODE | Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based… | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | M9G | 18 (best 0.85) |
| 6ODE | Crystal structure of mycobacterium tuberculosis proteasome in complex with phenylimidazole-based… | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | M9G | — |
| 7PXC | Substrate-engaged mycobacterial Proteasome-associated ATPase in complex with open-gate 20S CP… | electron microscopy | H, J, L, M, N, P, R, S, U, V, W, Y, a, b | — | 14 (best 0.85) |
| P9WHT9 | AlphaFold monomer V2.0 prediction for proteasome subunit beta (P9WHT9) | predicted | A | — | 2 (best 0.40) |
Ligands
- M9G · N-{(2S)-1-({(1S)-1-[5-(2-fluorophenyl)-1H-imidazol-2-yl]ethyl}amino)-1,4-dioxo-4-[(2R)-2-phenylpyrrolidin-1-yl]butan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide · in 2 records
- M6M · N-{(2S)-1-({(2S)-1-[(2,4-difluorobenzyl)amino]-1-oxopropan-2-yl}amino)-4-[(2S)-2-methylpiperidin-1-yl]-1,4-dioxobutan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide (non-preferred name) · in 1 record
- M6Y · N-{(2S)-1-({(2S)-1-[(2,4-difluorobenzyl)amino]-1-oxopropan-2-yl}amino)-1,4-dioxo-4-[(2R)-2-phenylpyrrolidin-1-yl]butan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide (non-preferred name) · in 1 record
Experiment against prediction
- 6ODE chain W against the predicted model P9WHT9: TM-score 1.00, RMSD 0.34 Å
- 6OCW chain H against the predicted model P9WHT9: TM-score 1.00, RMSD 0.34 Å
- 7PXC chain H against the predicted model P9WHT9: TM-score 1.00, RMSD 0.34 Å
- 5LZP chain A against the predicted model P9WHT9: TM-score 1.00, RMSD 0.34 Å
- 5LZP chain A against the predicted model P9WHT9: TM-score 1.00, RMSD 0.34 Å
- 5LZP chain O against the predicted model P9WHT9: TM-score 1.00, RMSD 0.34 Å
- 7PXC chain V against the predicted model P9WHT9: TM-score 1.00, RMSD 0.34 Å
- 5LZP chain F against the predicted model P9WHT9: TM-score 1.00, RMSD 0.35 Å
- 7PXC chain M against the predicted model P9WHT9: TM-score 1.00, RMSD 0.35 Å
- 5LZP chain U against the predicted model P9WHT9: TM-score 1.00, RMSD 0.35 Å
Elsewhere
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