UniProt P9WHU1
Proteasome subunit alpha (P9WHU1)
Proteasome subunit alpha (UniProt P9WHU1), EC 3.4.25.1: 7 experimental structures and 1 predicted model on GenesisL1, 38 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P9WHU1
- Protein
- Proteasome subunit alpha
- EC
- 3.4.25.1
- Experimental structures
- 7
- Predicted models
- 1
- Pockets
- 38 · 3 records with a druggable one
Structures
8 records of P9WHU1 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LZP | Binding of the C-terminal GQYL motif of the bacterial proteasome activator Bpa to the 20S proteasome | electron microscopy | 0, 2, 4, 6, 8, B, D, H, J, M, Q, S, W, Y | — | 14 (best 0.86) |
| 5LZP | Binding of the C-terminal gqyl motif of the bacterial proteasome activator bpa to the 20S proteasome | electron microscopy | 0, 2, 4, 6, 8, B, D, H, J, M, Q, S, W, Y | — | — |
| 6OCW | Crystal structure of mycobacterium tuberculosis proteasome in complex with phenylimidazole-based… | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 6OCZ | Crystal structure of mycobacterium tuberculosis proteasome in complex with phenylimidazole-based… | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 6ODE | Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based… | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | 13 (best 0.85) |
| 6ODE | Crystal structure of mycobacterium tuberculosis proteasome in complex with phenylimidazole-based… | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 7PXC | Substrate-engaged mycobacterial Proteasome-associated ATPase in complex with open-gate 20S CP… | electron microscopy | 0, 2, 4, 6, 8, I, K, O, Q, T, X, Z, d, f | — | 8 (best 0.85) |
| P9WHU1 | AlphaFold monomer V2.0 prediction for proteasome subunit alpha (P9WHU1) | predicted | A | — | 3 (best 0.35) |
Experiment against prediction
- 5LZP chain B against the predicted model P9WHU1: TM-score 0.99, RMSD 0.42 Å
- 5LZP chain B against the predicted model P9WHU1: TM-score 0.99, RMSD 0.42 Å
- 7PXC chain I against the predicted model P9WHU1: TM-score 0.99, RMSD 0.42 Å
- 7PXC chain K against the predicted model P9WHU1: TM-score 0.99, RMSD 0.43 Å
- 5LZP chain D against the predicted model P9WHU1: TM-score 0.99, RMSD 0.43 Å
- 5LZP chain D against the predicted model P9WHU1: TM-score 0.99, RMSD 0.43 Å
- 7PXC chain 0 against the predicted model P9WHU1: TM-score 0.99, RMSD 0.49 Å
- 5LZP chain 0 against the predicted model P9WHU1: TM-score 0.99, RMSD 0.50 Å
- 5LZP chain 0 against the predicted model P9WHU1: TM-score 0.99, RMSD 0.50 Å
- 6OCW chain G against the predicted model P9WHU1: TM-score 0.99, RMSD 0.54 Å
Elsewhere
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